Coherent encoding of subjective spatial position in visual cortex and hippocampus.
Coherent encoding of subjective spatial position in visual cortex and hippocampus.
复制标题
视觉皮层和海马体主观空间位置的连贯编码。
DOI：
10.1038/s41586-018-0516-1
复制
发表时间：
2018-10
期刊：
影响因子：
64.8
通讯作者：
Carandini M
中科院分区：
文献类型：
--
作者：
Saleem AB;Diamanti EM;Fournier J;Harris KD;Carandini M
视觉的一个主要作用是引导导航，而导航是由视觉强烈驱动的。事实上，众所周知，大脑的视觉和导航系统是相互作用的，并且与环境中的位置相关的信号最早出现在视觉皮层中。为了确定这些信号的性质，当小鼠在虚拟现实中穿过走廊时，我们在初级视觉皮层 (V1) 和海马区 CA1 中记录了这些信号。走廊在两个位置包含相同的视觉地标，因此纯视觉神经元在这些位置会做出类似的反应。然而，大多数 V1 神经元对一个位置的标志物仅做出或更强烈的反应。这种空间位置对视觉反应的调节不能用跑步速度等因素来解释。为了评估这种调制是否与导航信号和动物对位置的主观估计有关，我们训练小鼠在到达走廊的奖励区域时舔水以获取水奖励。 CA1 和 V1 中的神经元群对动物沿走廊的位置进行编码，并且它们表示的错误是相关的。此外，这两种表示都反映了动物对位置的主观估计，这是从动物的舔中推断出来的，比其实际位置更好。事实上，当动物舔特定位置时——无论正确还是错误——V1 和 CA1 中的神经群都会将动物置于奖励区。我们得出的结论是，V1 的视觉反应是由导航信号控制的，导航信号与海马体中编码的信号一致，反映了动物的主观位置。这种导航信号早在初级感觉区域就存在，这表明它们渗透到皮层的感觉处理过程中。
A major role of vision is to guide navigation, and navigation is strongly driven by vision. Indeed, the brain’s visual and navigational systems are known to interact, and signals related to position in the environment have been suggested to appear as early as in visual cortex. To establish the nature of these signals we recorded in primary visual cortex (V1) and in hippocampal area CA1 while mice traversed a corridor in virtual reality. The corridor contained identical visual landmarks in two positions, so that a purely visual neuron would respond similarly in those positions. Most V1 neurons, however, responded solely or more strongly to the landmarks in one position. This modulation of visual responses by spatial location was not explained by factors such as running speed. To assess whether the modulation is related to navigational signals and to the animal’s subjective estimate of position, we trained the mice to lick for a water reward upon reaching a reward zone in the corridor. Neuronal populations in both CA1 and V1 encoded the animal’s position along the corridor, and the errors in their representations were correlated. Moreover, both representations reflected the animal’s subjective estimate of position, inferred from the animal’s licks, better than its actual position. Indeed, when animals licked in a given location – whether correct or incorrect – neural populations in both V1 and CA1 placed the animal in the reward zone. We conclude that visual responses in V1 are controlled by navigational signals, which are coherent with those encoded in hippocampus and reflect the animal’s subjective position. The presence of such navigational signals as early as in a primary sensory area suggests that they permeate sensory processing in the cortex.
登录
查看更多内容
影响因子：
2.9
作者：
Kadir SN;Goodman DF;Harris KD
通讯作者：
Harris KD
影响因子：
16.2
作者：
Aronov, Dmitriy;Tank, David W.
通讯作者：
Tank, David W.
影响因子：
5.3
作者：
Hok, Vincent;Lenck-Santini, Pierre-Pascal;Poucet, Bruno
通讯作者：
Poucet, Bruno
影响因子：
25
作者：
Ji, Daoyun;Wilson, Matthew A.
通讯作者：
Wilson, Matthew A.
影响因子：
16.2
作者：
Niell CM;Stryker MP
通讯作者：
Stryker MP