Modulation of visual responses by behavioral state in mouse visual cortex.
Modulation of visual responses by behavioral state in mouse visual cortex.
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DOI：
10.1016/j.neuron.2010.01.033
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发表时间：
2010-02-25
期刊：
影响因子：
16.2
通讯作者：
Stryker MP
中科院分区：
文献类型：
--
作者：
Niell CM;Stryker MP
啮齿类动物的视觉处理研究通常在麻醉动物中进行，排除了行为对视觉诱发反应影响的检查。我们现在已经研究了清醒小鼠的初级视觉皮层神经元的反应特性，这些小鼠被允许在头部固定的情况下在自由旋转的球形跑步机上跑步。大多数神经元表现出超过一倍的视觉诱发放电率的动物从静止到运行，没有自发放电或刺激选择性的变化。在清醒的动物调谐性能类似于先前在麻醉动物中测得的。在外侧膝状体核的反应幅度并没有增加运动，表明显着的变化，反应并没有导致周边的影响，在眼睛。有趣的是，一些窄峰细胞在跑步过程中自发活跃，但受到视觉刺激的抑制。这些结果表明，在清醒的小鼠中，行为状态对视觉处理具有强大的细胞类型特异性调制。
Studies of visual processing in rodents have conventionally been performed in anesthetized animals, precluding examination of the effects of behavior on visually-evoked responses. We have now studied the response properties of neurons in primary visual cortex of awake mice that were allowed to run on a freely rotating spherical treadmill with their heads fixed. Most neurons showed more than a doubling of visually-evoked firing rate as the animal transitioned from standing still to running, without changes in spontaneous firing or stimulus selectivity. Tuning properties in the awake animal were similar to those measured previously in anesthetized animals. Response magnitude in the lateral geniculate nucleus did not increase with locomotion, demonstrating that the striking change in responsiveness did not result from peripheral effects at the eye. Interestingly, some narrow-spiking cells were spontaneously active during running but suppressed by visual stimuli. These results demonstrate powerful cell type-specific modulation of visual processing by behavioral state in awake mice.
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