Magnetic Particle Imaging-Guided Heating in Vivo Using Gradient Fields for Arbitrary Localization of Magnetic Hyperthermia Therapy.
Magnetic Particle Imaging-Guided Heating in Vivo Using Gradient Fields for Arbitrary Localization of Magnetic Hyperthermia Therapy.
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DOI：
10.1021/acsnano.8b00893
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发表时间：
2018-04-24
期刊：
影响因子：
17.1
通讯作者：
Conolly SM
中科院分区：
文献类型：
--
作者：
Tay ZW;Chandrasekharan P;Chiu-Lam A;Hensley DW;Dhavalikar R;Zhou XY;Yu EY;Goodwill PW;Zheng B;Rinaldi C;Conolly SM
图像引导的癌症治疗使医生能够非常精确地定位和治疗肿瘤。在这里，我们展示的活体结果表明，一种新兴的成像方式，磁粒子成像(MPI)，可以与磁热疗相结合，形成图像引导的治疗平台。MPI是一种非侵入性的三维断层成像方法，具有高灵敏度和对比度，零电离辐射，在任何深度都是线性定量的，没有视野限制。在MPI中成像的相同的超顺磁性纳米氧化铁(SPIONS)示踪剂也可以被激发来产生热，用于磁热疗。在这项研究中，我们展示了一种治疗平台，该平台具有用于治疗计划的定量MPI图像指导，并使用MPI梯度来将磁热疗的空间定位到任意选择的区域。这解决了传统磁热疗的一个关键挑战--SPION在靶外器官(如肝和脾)中系统性积聚，而热疗定位困难会导致这些器官的附带热损伤。使用MPI-磁热疗工作流程，我们演示了图像引导下的热疗对肿瘤的空间定位，同时将对附近肝脏(1-2厘米远)的附带损害降至最低。通过荧光素酶活性和组织学评估对热损伤的定位和治疗进行验证。除了热疗的局部化，本文提出的技术还可以扩展到药物释放的局部化驱动和其他基于生物力学的治疗。MPI具有高对比度和高灵敏度的成像，结合了驱动治疗的精确控制和定位，是磁基治疗的强大平台。
Image guided treatment of cancer enables physicians to localize and treat tumors with great precision. Here, we present in vivo results showing that an emerging imaging modality, Magnetic Particle Imaging (MPI), can be combined with Magnetic Hyperthermia into a image-guided theranostic platform. MPI is a noninvasive 3D tomographic imaging method with high sensitivity and contrast, zero ionizing radiation, and is linearly quantitative at any depth with no view limitations. The same superparamagnetic iron oxide nanoparticle (SPIONs) tracers imaged in MPI can also be excited to generate heat for magnetic hyperthermia. In this study, we demonstrate a theranostic platform, with quantitative MPI image-guidance for treatment planning and use of the MPI gradients for spatial localization of magnetic hyperthermia to arbitrarily selected regions. This addresses a key challenge of conventional magnetic hyperthermia - SPIONs delivered systemically accumulate in off-target organs (e.g., liver and spleen), and difficulty in localizing hyperthermia results in collateral heat damage to these organs. Using a MPI-magnetic hyperthermia workflow, we demonstrate image-guided, spatial localization of hyperthermia to the tumor while minimizing collateral damage to the nearby liver (1 – 2 cm distant). Localization of thermal damage and therapy was validated with luciferase activity and histological assessment. Apart from localizing thermal therapy, the technique presented here can also be extended to localize actuation of drug release and other biomechanical-based therapies. With high contrast and high sensitivity imaging combined with precise control and localization of the actuated therapy, MPI is a powerful platform for magnetic-based theranostics.
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