The IMGT/HLA database.
The IMGT/HLA database.
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DOI：
10.1093/nar/gkn662
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发表时间：
2009-01
影响因子：
14.9
通讯作者：
Marsh SG
中科院分区：
文献类型：
--
作者：
Robinson J;Waller MJ;Fail SC;McWilliam H;Lopez R;Parham P;Marsh SG
自IMGT/HLA数据库发布以来已有10年，为HLA社区提供了高度策划的HLA序列的可搜索存储库。HLA复合体位于人类6号染色体的6p21.3区域内，包含220多个不同功能的基因。许多基因编码免疫系统的蛋白质，并且具有高度多态性。这些HLA基因和等位基因的命名及其质量控制由WHO HLA系统因子命名委员会负责。通过HLA信息学小组的工作，并与欧洲生物信息学研究所合作，我们能够通过网站http://www.ebi.ac.uk/imgt/hla/向公众提供这些数据。第一个版本包含964个序列，最新版本包含3300个序列，每年增加约450个新序列。网站上提供的工具已经更新，以允许更复杂的比对，其中包括基因组序列数据，以及探针和引物设计工具的开发和HLA字典中的数据的纳入。定期更新网站，确保新的和确认的序列被分散到HLA社区，以及更广泛的研究和临床社区。
It is 10 years since the IMGT/HLA database was released, providing the HLA community with a searchable repository of highly curated HLA sequences. The HLA complex is located within the 6p21.3 region of human chromosome 6 and contains more than 220 genes of diverse function. Many of the genes encode proteins of the immune system and are highly polymorphic. The naming of these HLA genes and alleles, and their quality control is the responsibility of the WHO Nomenclature Committee for Factors of the HLA System. Through the work of the HLA Informatics Group and in collaboration with the European Bioinformatics Institute, we are able to provide public access to this data through the website http://www.ebi.ac.uk/imgt/hla/. The first release contained 964 sequences, the most recent release 3300 sequences, with around 450 new sequences been added each year. The tools provided on the website have been updated to allow more complex alignments, which include genomic sequence data, as well as the development of tools for probe and primer design and the inclusion of data from the HLA Dictionary. Regular updates to the website ensure that new and confirmatory sequences are dispersed to the HLA community, and the wider research and clinical communities.
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影响因子：
--
作者：
MARSH, SGE;BODMER, JG
通讯作者：
BODMER, JG
影响因子：
--
作者：
MARSH, SGE;BODMER, JG
通讯作者：
BODMER, JG
影响因子：
--
作者：
MARSH, SGE;BODMER, JG
通讯作者：
BODMER, JG
影响因子：
2.2
作者：
Schreuder, GMT;Hurley, CK;Maiers, M
通讯作者：
Maiers, M
影响因子：
14.9
作者：
Robinson, J;Waller, MJ;Marsh, SGE
通讯作者：
Marsh, SGE