A novel social fear conditioning procedure alters social behavior and mTOR signaling in differentially housed adolescent rats.
A novel social fear conditioning procedure alters social behavior and mTOR signaling in differentially housed adolescent rats.
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DOI：
10.1002/dev.22001
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发表时间：
2021-01
影响因子：
2.2
通讯作者：
Bland ST
中科院分区：
文献类型：
--
作者：
Dawud LM;Loetz EC;Lloyd B;Beam R;Tran S;Cowie K;Browne K;Khan T;Montoya R;Greenwood BN;Bland ST
易受恐惧相关疾病的影响可能会在早期生活逆境后增强。本研究旨在确定是否断奶后的社会隔离（PSI），早期生活逆境的动物模型，改变了社会恐惧的条件社会恐惧的创新模型的发展。雄性和雌性Sprague-Dawley大鼠在断奶后进行为期4周的社会饲养（SR）或PSI。然后将大鼠分配到由仅足电击、仅社会条件刺激（CS）或配对足电击与社会CS组成的组。第二天评估了社会行为。我们在PSI大鼠中观察到了一种新的行为反应，即绕圈奔跑，这在SR大鼠中很少观察到;此外，在PSI大鼠中进行配对治疗后，这种行为得到了增强。其他社会行为改变了PSI和成对的足电击和社会CS。哺乳动物雷帕霉素靶蛋白（mTOR）通路使用磷酸化核糖体蛋白S6（pS 6）在前额叶皮层（PFC）和杏仁核的亚区的免疫组织化学进行了评估。配对治疗产生相反的效果，在男性的PFC和杏仁核，但没有观察到女性的差异。条件性社交恐惧导致社交行为和mTOR通路的改变，这些改变取决于养育条件和性别。
Vulnerabilities to fear-related disorders can be enhanced following early life adversity. This study sought to determine whether post-weaning social isolation (PSI), an animal model of early life adversity, alters the development of social fear in an innovative model of conditioned social fear. Male and female Sprague-Dawley rats underwent either social rearing (SR) or PSI for 4 weeks following weaning. Rats were then assigned to groups consisting of either Footshock only, Social conditioned stimulus (CS) only, or Paired footshock with a social CS. Social behavior was assessed the next day. We observed a novel behavioral response in PSI rats, running in circles, that was rarely observed in SR rats; moreover, this behavior was augmented after Paired treatment in PSI rats. Other social behaviors were altered by both PSI and Paired footshock and social CS. The mammalian target of rapamycin (mTOR) pathway was assessed using immunohistochemistry for phosphorylated ribosomal protein S6 (pS6) in subregions of the prefrontal cortex (PFC) and amygdala. Paired treatment produced opposite effects in the PFC and amygdala in males, but no differences were observed in females. Conditioned social fear produced alterations in social behavior and the mTOR pathway that are dependent upon rearing condition and sex.
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影响因子：
3.4
作者：
Pezzato, Fernanda A.;Can, Adem;Hoshino, Katsumasa;Horta, Jose de Anchieta C., Jr.;Mijares, Miriam G.;Gould, Todd D.
通讯作者：
Gould, Todd D.
DOI：
10.1007/7854_2015_401
发表时间：
2016-01-01
期刊：
BEHAVIORAL NEUROSCIENCE OF MOTIVATION
影响因子：
--
作者：
Campese, Vincent D.;Sears, Robert M.;LeDoux, Joseph E.
通讯作者：
LeDoux, Joseph E.
影响因子：
7.7
作者：
Gruene, Tina M.;Flick, Katelyn;Shansky, Rebecca M.
通讯作者：
Shansky, Rebecca M.
影响因子：
5.7
作者：
Hahn, Andreas;Stein, Patrycja;Lanzenberger, Rupert
通讯作者：
Lanzenberger, Rupert
影响因子：
15.9
作者：
Hoeffer, Charles A.;Klann, Eric
通讯作者：
Klann, Eric