Enhancing motor learning by increasing the stability of newly formed dendritic spines in the motor cortex.
Enhancing motor learning by increasing the stability of newly formed dendritic spines in the motor cortex.
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DOI：
10.1016/j.neuron.2021.07.030
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发表时间：
2021-10-20
期刊：
影响因子：
16.2
通讯作者：
Ding JB
中科院分区：
文献类型：
--
作者：
Albarran E;Raissi A;Jáidar O;Shatz CJ;Ding JB
树突脊柱动力学被认为是运动学习和记忆的基础，脊柱动力学的改变经常导致表现受损。在这里，我们通过研究缺乏配对免疫球蛋白受体B （PirB−/−）的小鼠来描述这一规则的例外。PirB - / -小鼠的锥体神经元树突增加了脊柱形成率和密度。令人惊讶的是，PirB - / -小鼠比野生型（WT）幼崽更快地学会了技巧接触任务。此外，PirB - / -小鼠的学习诱导的脊柱稳定性也有所提高。从机制上讲，单脊柱解栓实验表明，PirB是nmda依赖性脊柱收缩所必需的。新形成的脊柱的存活程度与表现相关，这表明脊柱稳定性的增加有利于学习。值得注意的是，在成年WT小鼠M1中急性抑制PirB功能可增加学习诱导脊髓的存活率并增强运动学习。这些结果表明，即使在成年期，也可以通过操纵PirB来解除运动学习的限制。运动皮层树突棘的动态变化对运动学习至关重要。Albarran等人表明，阻断PirB功能可以增强运动学习和表现，从而解除nmdar依赖性脊柱收缩和有限，从而增加脊柱稳定性和密度。
Dendritic spine dynamics are thought to be substrates for motor learning and memory and altered spine dynamics often lead to impaired performance. Here we describe an exception to this rule by studying mice lacking Paired immunoglobulin receptor B (PirB−/−). Pyramidal neuron dendrites in PirB−/− mice have increased spine formation rates and density. Surprisingly, PirB−/− mice learn a skilled-reaching task faster than wild type (WT) littermates. Furthermore, the stabilization of learning-induced spines is elevated in PirB−/− mice. Mechanistically, single spine uncaging experiments suggest that PirB is required for NMDAR-dependent spine shrinkage. The degree of survival of newly-formed spines correlates with performance, suggesting that increased spine stability is advantageous for learning. Notably, inhibiting PirB function acutely in M1 of adult WT mice increases the survival of learning-induced spines and enhances motor learning. These results demonstrate that there are limits on motor learning that can be lifted by manipulating PirB, even in adulthood. Dynamic changes of dendritic spines in motor cortex are critical for motor learning. Albarran et al. show that motor learning and performance can be enhanced by blocking PirB function, which disengages NMDAR-dependent spine shrinkage and LTD, resulting in increased spine stability and density.
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影响因子：
64.8
作者：
Hayashi-Takagi A;Yagishita S;Nakamura M;Shirai F;Wu YI;Loshbaugh AL;Kuhlman B;Hahn KM;Kasai H
通讯作者：
Kasai H
影响因子：
16.6
作者：
Frank AC;Huang S;Zhou M;Gdalyahu A;Kastellakis G;Silva TK;Lu E;Wen X;Poirazi P;Trachtenberg JT;Silva AJ
通讯作者：
Silva AJ
影响因子：
25
作者：
Hayama, Tatsuya;Noguchi, Jun;Watanabe, Satoshi;Takahashi, Noriko;Hayashi-Takagi, Akiko;Ellis-Davies, Graham C. R.;Matsuzaki, Masanori;Kasai, Haruo
通讯作者：
Kasai, Haruo
DOI：
10.1126/science.aao0862
发表时间：
2018-06-22
期刊：
Science (New York, N.Y.)
影响因子：
--
作者：
El-Boustani S;Ip JPK;Breton-Provencher V;Knott GW;Okuno H;Bito H;Sur M
通讯作者：
Sur M
影响因子：
5.3
作者：
Harms, Kimberly J.;Rioult-Pedotti, Mengia S.;Dunaevsky, Anna
通讯作者：
Dunaevsky, Anna