Convergent evidence from multimodal imaging reveals amygdala abnormalities in schizophrenic patients and their first-degree relatives.
Convergent evidence from multimodal imaging reveals amygdala abnormalities in schizophrenic patients and their first-degree relatives.
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来自多模态成像的汇聚证据揭示了精神分裂症患者及其一级亲属的杏仁核异常
DOI：
10.1371/journal.pone.0028794
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发表时间：
2011
期刊：
影响因子：
3.7
通讯作者：
Zhang D
中科院分区：
文献类型：
--
作者：
Tian L;Meng C;Yan H;Zhao Q;Liu Q;Yan J;Han Y;Yuan H;Wang L;Yue W;Zhang Y;Li X;Zhu C;He Y;Zhang D
精神分裂症患者及其一级亲属之间共有的神经病理学特征可能是精神分裂症遗传易感性的指标。我们试图探索精神分裂症患者及其亲属的脑形态和功能的遗传影响。方法采用多模式成像策略，我们研究了33例精神分裂症患者，55例未受影响的父母，30例健康对照患者，29例健康对照父母的结构MRI扫描的基于体素的形态测量和静息状态功能MRI数据的功能连接分析。结果精神分裂症患者双侧额叶皮质、双侧岛叶、双侧枕叶皮质、左侧杏仁核和右侧丘脑灰质广泛减少，而其父母的左侧杏仁核、左侧丘脑和右侧眶额皮质灰质减少较局限。患者和他们的父母都有左侧杏仁核的灰质损失。对患者杏仁核静息状态功能连接的进一步研究显示，与双侧眶额皮质、双侧楔前叶、双侧背外侧额叶皮质和右侧杏仁核的功能连接异常。他们的父母在杏仁核连接模式上表现出的变化略少，但相似。在精神分裂症患者及其父母中观察到左侧杏仁核与左侧眶额皮质、右侧背外侧额叶皮质和右侧楔前叶的异常连接的共同发生。结论精神分裂症患者杏仁核的结构和功能异常可能与遗传因素有关。这些信息可以帮助未来的努力，以确定内表型的特点，复杂的精神分裂症。
Background Shared neuropathological features between schizophrenic patients and their first-degree relatives have potential as indicators of genetic vulnerability to schizophrenia. We sought to explore genetic influences on brain morphology and function in schizophrenic patients and their relatives. Methods Using a multimodal imaging strategy, we studied 33 schizophrenic patients, 55 of their unaffected parents, 30 healthy controls for patients, and 29 healthy controls for parents with voxel-based morphometry of structural MRI scans and functional connectivity analysis of resting-state functional MRI data. Results Schizophrenic patients showed widespread gray matter reductions in the bilateral frontal cortices, bilateral insulae, bilateral occipital cortices, left amygdala and right thalamus, whereas their parents showed more localized reductions in the left amygdala, left thalamus and right orbitofrontal cortex. Patients and their parents shared gray matter loss in the left amygdala. Further investigation of the resting-state functional connectivity of the amygdala in the patients showed abnormal functional connectivity with the bilateral orbitofrontal cortices, bilateral precunei, bilateral dorsolateral frontal cortices and right insula. Their parents showed slightly less, but similar changes in the pattern in the amygdala connectivity. Co-occurrences of abnormal connectivity of the left amygdala with the left orbitofrontal cortex, right dorsolateral frontal cortex and right precuneus were observed in schizophrenic patients and their parents. Conclusions Our findings suggest a potential genetic influence on structural and functional abnormalities of the amygdala in schizophrenia. Such information could help future efforts to identify the endophenotypes that characterize the complex disorder of schizophrenia.
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