Integrated analyses identify a master microRNA regulatory network for the mesenchymal subtype in serous ovarian cancer.
Integrated analyses identify a master microRNA regulatory network for the mesenchymal subtype in serous ovarian cancer.
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综合分析确定了浆液性卵巢癌间充质亚型的主要 microRNA 调控网络。
DOI：
10.1016/j.ccr.2012.12.020
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发表时间：
2013-02-11
期刊：
影响因子：
50.3
通讯作者：
Zhang W
中科院分区：
文献类型：
--
作者：
Yang D;Sun Y;Hu L;Zheng H;Ji P;Pecot CV;Zhao Y;Reynolds S;Cheng H;Rupaimoole R;Cogdell D;Nykter M;Broaddus R;Rodriguez-Aguayo C;Lopez-Berestein G;Liu J;Shmulevich I;Sood AK;Chen K;Zhang W
整合的基因组分析揭示了一个miRNA调控网络，进一步定义了一个强大的整合间充质亚型，该亚型与来自癌症基因组图谱的459例浆液性卵巢癌（OvCa）和来自独立队列的560例病例的总生存率差相关。包括miR-506、miR-141和miR-200 a在内的8种关键miRNAs被预测调控该网络中89%的靶点。后续功能实验表明，miR-506通过靶向E-cadherin的转录抑制因子SNAI 2，增强E-cadherin表达，抑制细胞迁移和侵袭，并阻止TGFβ诱导的上皮-间质转化（EMT）。在人类OvCa中，miR-506表达与SNAI 2和Vim降低、E-cadherin升高和有益预后相关。在原位OvCa小鼠模型中miR-506的纳米颗粒递送导致E-钙粘蛋白诱导和减少的肿瘤生长。
Integrated genomic analyses revealed a miRNA-regulatory network, which further defined a robust integrated mesenchymal subtype associated with poor overall survival in 459 cases of serous ovarian cancer (OvCa) from The Cancer Genome Atlas and 560 cases from independent cohorts. Eight key miRNAs, including miR-506, miR-141 and miR-200a, were predicted to regulate 89% of the targets in this network. Follow-up functional experiments illustrate that miR-506 augmented E-cadherin expression, inhibited cell migration and invasion, and prevented TGFβ-induced epithelial-mesenchymal transition (EMT) by targeting SNAI2, a transcriptional repressor of E-cadherin. In human OvCa, miR-506 expression was correlated with decreased SNAI2 and VIM, elevated E-cadherin, and beneficial prognosis. Nanoparticle delivery of miR-506 in orthotopic OvCa mouse models led to E-cadherin induction and reduced tumor growth.
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影响因子：
11.5
作者：
Rosano, Laura;Cianfrocca, Roberta;Bagnato, Anna
通讯作者：
Bagnato, Anna
DOI：
10.1038/nrc2644
发表时间：
2009-06
期刊：
Nature reviews. Cancer
影响因子：
--
作者：
通讯作者：
--
影响因子：
64.5
作者：
Lewis, BP;Shih, IH;Burge, CB
通讯作者：
Burge, CB
影响因子：
254.7
作者：
Jemal, A;Tiwari, RC;Thun, MJ
通讯作者：
Thun, MJ
DOI：
10.1111/j.2517-6161.1995.tb02031.x
发表时间：
1995-01-01
影响因子：
5.8
作者：
BENJAMINI, Y;HOCHBERG, Y
通讯作者：
HOCHBERG, Y