Compositional Dynamics of the Milk Fat Globule and Its Role in Infant Development.
Compositional Dynamics of the Milk Fat Globule and Its Role in Infant Development.
复制标题
DOI：
10.3389/fped.2018.00313
复制
发表时间：
2018
影响因子：
2.6
通讯作者：
Slupsky C
中科院分区：
文献类型：
--
作者：
Lee H;Padhi E;Hasegawa Y;Larke J;Parenti M;Wang A;Hernell O;Lönnerdal B;Slupsky C
人乳是为发育中的婴儿的需求而独特优化的。它的组成是复杂和动态的，主要受母体遗传因素的影响，其次是饮食和环境。其中一个重要的成分是乳脂球（MFG）。MFG由三层膜包围的富含甘油三酯的核心组成，三层膜也称为源自乳腺上皮的乳脂球膜（MFGM）。MFGM富含甘油磷脂、鞘脂、胆固醇和蛋白质，其中一些是糖基化的，已知发挥多种生物学作用。越来越多的证据表明，MFG的结构和MFGM的生物活性成分可以通过在婴儿生长和免疫教育期间提供必需营养素和/或调节各种细胞事件来帮助肠道的结构和功能成熟，从而使婴儿受益。此外，MFG周围的抗微生物肽和表面碳水化合物部分可能在塑造肠道微生物种群中具有关键作用，这反过来又可以促进对生命早期免疫和炎症疾病的保护。审查的目的是：（1）了解MFG的成分，以及影响其特征的母体因素，包括遗传和生活方式因素;（2）检查这种牛奶成分对肠道免疫系统的潜在作用;（3）描述MFG在婴儿肠道成熟和消化道微生物群建立中的机制作用。
Human milk is uniquely optimized for the needs of the developing infant. Its composition is complex and dynamic, driven primarily by maternal genetics, and to a lesser extent by diet and environment. One important component that is gaining attention is the milk fat globule (MFG). The MFG is composed of a triglyceride-rich core surrounded by a tri-layer membrane, also known as the milk fat globule membrane (MFGM) that originates from mammary gland epithelia. The MFGM is enriched with glycerophospholipids, sphingolipids, cholesterol, and proteins, some of which are glycosylated, and are known to exert numerous biological roles. Mounting evidence suggests that the structure of the MFG and bioactive components of the MFGM may benefit the infant by aiding in the structural and functional maturation of the gut through the provision of essential nutrients and/or regulating various cellular events during infant growth and immune education. Further, antimicrobial peptides and surface carbohydrate moieties surrounding the MFG might have a pivotal role in shaping gut microbial populations, which in turn may promote protection against immune and inflammatory diseases early in life. This review seeks to: (1) understand the components of the MFG, as well as maternal factors including genetic and lifestyle factors that influence its characteristics; (2) examine the potential role of this milk component on the intestinal immune system; and (3) delineate the mechanistic roles of the MFG in infant intestinal maturation and establishment of the microbiota in the alimentary canal.
登录
查看更多内容
DOI：
10.1097/00005176-200309000-00014
发表时间：
2003-09-01
影响因子：
2.9
作者：
Brück, WM;Kelleher, SL;Lönnerdal, B
通讯作者：
Lönnerdal, B
影响因子：
4.7
作者：
Al-Tamer, Y. Y.;Mahmood, A. A.
通讯作者：
Mahmood, A. A.
影响因子：
6.3
作者：
Bauer, Jacqueline;Gerss, Joachim
通讯作者：
Gerss, Joachim
影响因子：
4.6
作者：
Bhinder G;Allaire JM;Garcia C;Lau JT;Chan JM;Ryz NR;Bosman ES;Graef FA;Crowley SM;Celiberto LS;Berkmann JC;Dyer RA;Jacobson K;Surette MG;Innis SM;Vallance BA
通讯作者：
Vallance BA
影响因子：
7.1
作者：
BITMAN, J;WOOD, DL;HAMOSH, M
通讯作者：
HAMOSH, M