Mitoquinone restores platelet production in irradiation-induced thrombocytopenia.
Mitoquinone restores platelet production in irradiation-induced thrombocytopenia.
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DOI：
10.3109/09537104.2014.935315
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发表时间：
2015
期刊：
影响因子：
3.3
通讯作者：
Wu MX
中科院分区：
文献类型：
--
作者：
Ramsey H;Zhang Q;Wu MX
Myelodysplastic syndromes (MDS) are hallmarked by cytopenia and dysplasia of hematopoietic cells, often accompanied by mitochondrial dysfunction and increases of reactive oxygen species (ROS) within affected cells. However, it is not known whether the increase in ROS production is an instigator or a byproduct of the disease. The present investigation shows that mice lacking immediate early responsive gene X-1 (IEX-1) exhibit lineage specific increases in ROS production and abnormal cytology upon radiation in blood cell types commonly identified in MDS. These affected cell lineages chiefly have the bone marrow as a primary site of differentiation and maturation, while cells with extramedullary differentiation and maturation like B- and T-cells remain unaffected. Increased ROS production is likely to contribute significantly to irradiation-induced thrombocytopenia in the absence of IEX-1 as demonstrated by effective reversal of the disorder after mitoquinone (MitoQ) treatment, a mitochondria-specific antioxidant. MitoQ reduced intracellular ROS production within megakaryocytes and platelets. It also normalized mitochondrial membrane potential and superoxide production in platelets in irradiated, IEX-1 deficient mice. The lineage-specific effects of mitochondrial ROS may help us understand the etiology of thrombocytopenia in association with MDS in a subgroup of the patients.
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DOI：
10.1523/jneurosci.0552-11.2011
发表时间：
2011-11-02
期刊：
The Journal of neuroscience : the official journal of the Society for Neuroscience
影响因子：
--
作者：
McManus MJ;Murphy MP;Franklin JL
通讯作者：
Franklin JL
影响因子：
20.3
作者：
Lewandowski, Daniel;Barroca, Vilma;Romeo, Paul-Henri
通讯作者：
Romeo, Paul-Henri
影响因子：
20.3
作者：
de Laval, Berengere;Pawlikowska, Patrycja;Porteu, Francoise
通讯作者：
Porteu, Francoise
影响因子：
3.1
作者：
Ghoti, Hussam;Amer, Johnny;Fibach, Eitan
通讯作者：
Fibach, Eitan
影响因子：
3.7
作者：
Challen, Grant A.;Boles, Nathan;Lin, Karen Kuan-Yin;Goodell, Margaret A.
通讯作者：
Goodell, Margaret A.