Recent Developments on the Roles of Calcium Signals and Potential Therapy Targets in Cervical Cancer.
Recent Developments on the Roles of Calcium Signals and Potential Therapy Targets in Cervical Cancer.
复制标题
钙信号在宫颈癌中的作用和潜在治疗靶点的最新进展。
作者：
细胞内钙离子浓度（[Ca2 +]i）与癌组织的增殖、侵袭和转移有关。各种肿瘤治疗和一些候选药物通过调节[Ca 2 +]i诱导其抗肿瘤作用（部分或全部）。宫颈癌是世界范围内女性最常见的癌症之一。近年来，有关宫颈癌中Ca2+信号的研究取得了重大进展。本文就Ca2+信号在宫颈癌发生、发展及预后中的作用作一综述。这将加深我们对宫颈癌中Ca2+信号的致病机制的理解，从而为寻找潜在的治疗靶点提供新的视角。
Intracellular calcium (Ca2+) concentration ([Ca2+]i) is implicated in proliferation, invasion, and metastasis in cancerous tissues. A variety of oncologic therapies and some candidate drugs induce their antitumor effects (in part or in whole) through the modulation of [Ca2+]i. Cervical cancer is one of most common cancers among women worldwide. Recently, major research advances relating to the Ca2+ signals in cervical cancer are emerging. In this review, we comprehensively describe the current progress concerning the roles of Ca2+ signals in the occurrence, development, and prognosis of cervical cancer. It will enhance our understanding of the causative mechanism of Ca2+ signals in cervical cancer and thus provide new sights for identifying potential therapeutic targets for drug discovery.
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作者：
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DOI：
10.1007/s00249-016-1142-1
发表时间：
2016-10
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作者：
Gaunt, Hannah J.;Vasudev, Naveen S.;Beech, David J.
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