Neural Coding With Bursts-Current State and Future Perspectives.

Neural Coding With Bursts-Current State and Future Perspectives.
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DOI:
10.3389/fncom.2018.00048
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发表时间:
2018
影响因子:
3.2
通讯作者:
Englitz B
Englitz B
中科院分区:
医学4区
文献类型:
--
作者:
Zeldenrust F;Wadman WJ;Englitz B

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神经元动作电位或尖峰提供神经元之间的长距离、抗噪声的通信手段。作为点过程,单个尖峰本身包含很少的信息,即,在其他神经元的尖峰之外。此外,它们可能无法穿过突触。由一串短而高频的尖峰组成的脉冲串将更可靠地穿过突触,增加引发突触后尖峰的可能性,这取决于该突触的特定短期可塑性。脉冲串中尖峰的数量和时间模式都提供了一个编码空间,该空间位于单个神经元的时间整合范围内。在许多物种中,包括非哺乳动物,以及从皮层下到皮层的大脑区域,都观察到了爆发。尽管其广泛存在和潜在的相关性,如何分类爆发的不确定性似乎限制了研究的编码可能性爆发。本系列的研究文章提供了新的见解的相关性和解释的爆发在不同的神经回路,并为他们的分析新方法。在这里,我们提供了一个简洁的介绍突发编码的历史和最近的工作在这个主题上的概述。
Neuronal action potentials or spikes provide a long-range, noise-resistant means of communication between neurons. As point processes single spikes contain little information in themselves, i.e., outside the context of spikes from other neurons. Moreover, they may fail to cross a synapse. A burst, which consists of a short, high frequency train of spikes, will more reliably cross a synapse, increasing the likelihood of eliciting a postsynaptic spike, depending on the specific short-term plasticity at that synapse. Both the number and the temporal pattern of spikes in a burst provide a coding space that lies within the temporal integration realm of single neurons. Bursts have been observed in many species, including the non-mammalian, and in brain regions that range from subcortical to cortical. Despite their widespread presence and potential relevance, the uncertainties of how to classify bursts seems to have limited the research into the coding possibilities for bursts. The present series of research articles provides new insights into the relevance and interpretation of bursts across different neural circuits, and new methods for their analysis. Here, we provide a succinct introduction to the history of burst coding and an overview of recent work on this topic.
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