Combined Diffusion Tensor Imaging and Arterial Spin Labeling as Markers of Early Parkinson's disease.
Combined Diffusion Tensor Imaging and Arterial Spin Labeling as Markers of Early Parkinson's disease.
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DOI：
10.1038/srep33762
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发表时间：
2016-09-20
影响因子：
4.6
通讯作者：
Wang Q
中科院分区：
文献类型：
--
作者：
Wei X;Yan R;Chen Z;Weng R;Liu X;Gao H;Xu X;Kang Z;Liu Z;Guo Y;Liu Z;Larsen JP;Wang J;Tang B;Hallett M;Wang Q
本研究旨在利用弥散张量成像（DTI）和动脉自旋标记（ASL）联合识别PD特异性MRI模式，以区分早期PD患者和健康受试者，并评估疾病状态。21例早期和22例中晚期PD患者以及22例健康、年龄/性别匹配的对照组接受了3-T MRI检查，测量了表观扩散系数（ADC）、分数各向异性（FA）、纤维数（FN）和脑血流量（CBF）。我们发现，与健康受试者相比，PD患者通过SN的FN显著减少。脑核内FA和尾状核内CBF与运动功能障碍呈负相关。海马（髋关节）FA与NMSS-Mood评分呈负相关，而髋关节和前额皮质（PFC） CBF与认知能力下降相关。分层五重交叉验证确定了SN中的FA (FA- snav)， PFC中的CBF （CBF- pfcav）和顶叶白质中的FA (FA- pwmav)，这些测量的组合在区分早期PD与健康受试者方面具有相对较高的准确性（AUC 0.975，灵敏度90%，特异性100%）。我们发现SN导致的FNs减少与FA-SNAv、CBF-PFCAv和FA-PWMAv值的变化可能是早期PD的潜在标志。
This study aimed to identify a PD-specific MRI pattern using combined diffusion tensor imaging (DTI) and arterial spin labeling (ASL) to discriminate patients with early PD from healthy subjects and evaluate disease status. Twenty-one early and 22 mid-late PD patients, and 22 healthy, age/gender-matched controls underwent 3-T MRI with apparent diffusion coefficient (ADC), fractional anisotropy (FA), fiber number (FN) and cerebral blood flow (CBF) measurements. We found that compared with healthy subjects, there was a profound reduction in FN passing through the SN in PD. FA in the SN and CBF in the caudate nucleus were inversely correlated with motor dysfunction. A negative correlation was observed between FA in the hippocampus (Hip) and the NMSS-Mood score, whereas CBF in the Hip and the prefrontal cortex(PFC) correlated with declined cognition. Stratified five-fold cross-validation identified FA in the SN(FA-SNAv), CBF in the PFC(CBF-PFCAv) and FA in the parietal white matter(FA-PWMAv), and the combination of these measurements offered relatively high accuracy (AUC 0.975, 90% sensitivity and 100% specificity) in distinguishing those with early PD from healthy subjects. We demonstrate that the decreased FNs through SN in combination with changes in FA-SNAv, CBF-PFCAv and FA-PWMAv values might serve as potential markers of early-stage PD.
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