Early Time-Restricted Feeding Improves Insulin Sensitivity, Blood Pressure, and Oxidative Stress Even without Weight Loss in Men with Prediabetes.
Early Time-Restricted Feeding Improves Insulin Sensitivity, Blood Pressure, and Oxidative Stress Even without Weight Loss in Men with Prediabetes.
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DOI：
10.1016/j.cmet.2018.04.010
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发表时间：
2018-06-05
期刊：
影响因子：
29
通讯作者：
Peterson CM
中科院分区：
文献类型：
--
作者：
Sutton EF;Beyl R;Early KS;Cefalu WT;Ravussin E;Peterson CM
间歇性禁食（IF）可以改善心脏代谢健康;然而，目前还不清楚这些影响是否仅仅是由于体重减轻。我们进行了第一次监督控制喂养试验，以测试IF是否具有独立于体重减轻的益处，通过喂养参与者足够的食物来维持他们的体重。我们的概念验证研究也构成了早期限时喂养（eTRF）的第一次试验，这是一种IF形式，涉及在一天的早期进食，以符合新陈代谢的昼夜节律。患有前驱糖尿病的男性被随机分配到eTRF（6小时喂养期，下午3点前晚餐）或对照计划（12小时喂养期），持续5周，然后交叉到另一个计划。eTRF改善胰岛素敏感性、β细胞反应性、血压、氧化应激和食欲。我们首次在人类中证明，eTRF改善了心脏代谢健康的某些方面，IF的作用不仅仅是由于体重减轻。萨顿等人进行了第一次监督控制喂养试验，以测试在没有体重减轻的情况下，间歇性禁食是否对人类有益。糖尿病前期的男性在进行一种称为早期限时喂养的间歇性禁食后，改善了他们的胰岛素敏感性、血压和氧化应激水平，而没有减轻体重。
Intermittent fasting (IF) improves cardiometabolic health; however, it is unknown whether these effects are due solely to weight loss. We conducted the first supervised controlled feeding trial to test whether IF has benefits independent of weight loss by feeding participants enough food to maintain their weight. Our proof-of-concept study also constitutes the first trial of early time-restricted feeding (eTRF), a form of IF that involves eating early in the day to be in alignment with circadian rhythms in metabolism. Men with prediabetes were randomized to eTRF (6-hour feeding period, with dinner before 3 pm) or a control schedule (12-hour feeding period) for five weeks and later crossed over to the other schedule. eTRF improved insulin sensitivity, β cell responsiveness, blood pressure, oxidative stress, and appetite. We demonstrate for the first time in humans that eTRF improves some aspects of cardiometabolic health and IF’s effects are not solely due to weight loss. Sutton et al. conduct the first supervised controlled feeding trial to test whether intermittent fasting has benefits in humans in the absence of weight loss. Prediabetic men following a form of intermittent fasting called early time-restricted feeding improved their insulin sensitivity, blood pressure, and oxidative stress levels, without losing weight.
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仅在发生大量体重减轻并与减肥幅度相关后，才能观察到胃旁路手术后的外周葡萄糖吸收的改善。
影响因子：
3.2
作者：
Campos, Guilherme M.;Rabl, Charlotte;Peeva, Sofia;Ciovica, Ruxandra;Rao, Madhu;Schwarz, Jean-Marc;Havel, Peter;Schambelan, Morris;Mulligan, Kathleen
通讯作者：
Mulligan, Kathleen
DOI：
10.3390/bs7010004
发表时间：
2017-01-19
期刊：
Behavioral sciences (Basel, Switzerland)
影响因子：
--
作者：
Harvie M;Howell A
通讯作者：
Howell A
DOI：
10.1186/s13058-016-0714-4
发表时间：
2016-05-28
期刊：
Breast cancer research : BCR
影响因子：
--
作者：
Harvie MN;Sims AH;Pegington M;Spence K;Mitchell A;Vaughan AA;Allwood JW;Xu Y;Rattray NJ;Goodacre R;Evans DG;Mitchell E;McMullen D;Clarke RB;Howell A
通讯作者：
Howell A
影响因子：
29
作者：
Brandhorst S;Choi IY;Wei M;Cheng CW;Sedrakyan S;Navarrete G;Dubeau L;Yap LP;Park R;Vinciguerra M;Di Biase S;Mirzaei H;Mirisola MG;Childress P;Ji L;Groshen S;Penna F;Odetti P;Perin L;Conti PS;Ikeno Y;Kennedy BK;Cohen P;Morgan TE;Dorff TB;Longo VD
通讯作者：
Longo VD
影响因子：
29
作者：
Hatori M;Vollmers C;Zarrinpar A;DiTacchio L;Bushong EA;Gill S;Leblanc M;Chaix A;Joens M;Fitzpatrick JA;Ellisman MH;Panda S
通讯作者：
Panda S