Developmental trajectories of the corpus callosum in attention-deficit/hyperactivity disorder.
Developmental trajectories of the corpus callosum in attention-deficit/hyperactivity disorder.
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DOI：
10.1016/j.biopsych.2010.11.024
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发表时间：
2011-05-01
影响因子：
10.6
通讯作者：
Shaw, Philip
中科院分区：
文献类型：
--
作者：
Gilliam, Mary;Stockman, Michael;Malek, Meaghan;Sharp, Wendy;Greenstein, Deanna;Lalonde, Francois;Clasen, Liv;Giedd, Jay;Rapoport, Judith;Shaw, Philip
关键词：
最近发现，患有注意力缺陷多动障碍（ADHD）的右撇子青少年的典型前额叶（而非后叶）皮质不对称发育被破坏。使用纵向数据，我们测试了前胼胝体生长的一致性中断的假设，其中包含连接前额皮质区域的白质束。通过对236名ADHD儿童和青少年（429次扫描）和230名正常发育的青少年（399次扫描）进行828次神经解剖磁共振扫描，使用半自动方法对胼胝体的五个亚区进行量化，其中大多数人进行了重复的神经成像。使用混合模型线性回归定义各诊断组的生长速率。右撇子ADHD参与者的胼胝体最前部区域的增长速度（估计年增长面积为0.97%,SEM 0.12%）明显高于正常发育的同龄人（年增长面积为0.32%,SEM 0.13%; t=3.64, p=0.0003）。在右撇子参与者中，在任何其他区域的生长速率没有发现显著的诊断差异，在非右撇子参与者中也没有发现显著的诊断差异。正如假设的那样，我们在ADHD患者的前胼胝体中发现了异常的生长轨迹。这种前胼胝体生长的中断可能反映甚至驱动了先前报道的前额皮质不对称发育的中断。这一发现证明了ADHD特征的胼胝体和前额皮质一致异常的动态、年龄依赖性。
It was recently found that the development of typical patterns of prefrontal, but not posterior, cortical asymmetry is disrupted in right handed youth with attention-deficit/hyperactivity disorder (ADHD). Using longitudinal data, we tested the hypothesis that there would be a congruent disruption in the growth of the anterior corpus callosum, which contains white matter tracts connecting prefrontal cortical regions. Areas of five subregions of the corpus callosum were quantified using a semiautomated method from 828 neuroanatomic magnetic resonance scans acquired from 236 children and adolescents with ADHD (429 scans) and 230 typically developing youth (399 scans), the majority of whom had repeated neuroimaging. Growth rates of each diagnostic group were defined using mixed-model linear regression. Right handed participants with ADHD showed a significantly higher rate of growth in the anterior-most region of the corpus callosum (estimated annual increase in area of 0.97%, SEM 0.12%) than their typically developing peers (annual increase in area of 0.32% SEM 0.13%; t=3.64, p=0.0003). No significant diagnostic differences in growth rates were found in any other regions in right handed participants, and no significant diagnostic differences were found in non-right handed participants. As hypothesized, we found anomalous growth trajectories in the anterior corpus callosum in ADHD. This disrupted anterior callosal growth may reflect, or even drive, the previously reported disruption in the development of prefrontal cortex asymmetry. The finding documents the dynamic, age-dependent nature of callosal and congruent prefrontal cortical abnormalities characterizing ADHD.
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影响因子：
3
作者：
Hale TS;Loo SK;Zaidel E;Hanada G;Macion J;Smalley SL
通讯作者：
Smalley SL
DOI：
10.1111/j.1469-7610.2006.01671.x
发表时间：
2006-10-01
影响因子：
7.6
作者：
Dickstein, Steven G.;Bannon, Katie;Milham, Michael P.
通讯作者：
Milham, Michael P.
影响因子：
9.9
作者：
Baumgardner, TL;Singer, HS;Reiss, AL
通讯作者：
Reiss, AL
DOI：
10.3109/15622970209150624
发表时间：
2002-10-01
期刊：
The world journal of biological psychiatry : the official journal of the World Federation of Societies of Biological Psychiatry
影响因子：
--
作者：
Bussing, Regina;Grudnik, Jennifer;Leonard, Christiana
通讯作者：
Leonard, Christiana
影响因子：
3.8
作者：
Bedeschi, MF;Bonaglia, MC;Borgatti, R
通讯作者：
Borgatti, R