Nanotechnology for research and treatment of the intestine.
Nanotechnology for research and treatment of the intestine.
复制标题
用于肠道研究和治疗的纳米技术。
DOI：
10.1186/s12951-022-01517-3
复制
发表时间：
2022-09-29
影响因子：
10.2
通讯作者：
Fang, Jun
中科院分区：
文献类型：
--
作者：
Fei, Yanquan;Ma, Yong;Zhang, Huaizu;Li, Hao;Feng, Guangfu;Fang, Jun
肠道体外模型的建立对于阐明肠道细胞-微生物的内在联系和相互作用机制，促进肠道疾病的规范化诊断和精准治疗具有重要意义。本文结合纳米支架在肠道体外模型中的研究，对纳米材料在黏膜治疗中的应用及机制研究进行综述。通过回顾不同物理化学原理合成的纳米材料的原始性质，并对原始性质进行修饰，探讨纳米材料对解决传统肠道模型中存活期短、细胞分化率低、还原能力差等问题的贡献。根据纳米材料不同的诊断介质和治疗靶点，归纳总结了目前在炎症性肠病、肠癌等疾病中的诊断原则。此外，还讨论了纳米药物在修复粘膜、抑制炎症、缓解疾病过程中的作用机制。通过这种系统的阐述，它为纳米材料提供了基础，以帮助推进肠道的体外研究，并在临床上提供精确的治疗。
The establishment of intestinal in vitro models is crucial for elucidating intestinal cell-microbe intrinsic connections and interaction mechanisms to advance normalized intestinal diagnosis and precision therapy. This review discusses the application of nanomaterials in mucosal therapy and mechanism research in combination with the study of nanoscaffold in vitro models of the gut. By reviewing the original properties of nanomaterials synthesized by different physicochemical principles and modifying the original properties, the contribution of nanomaterials to solving the problems of short survival period, low cell differentiation rate, and poor reduction ability in traditional intestinal models is explored. According to nanomaterials’ different diagnostic mediators and therapeutic targets, the current diagnostic principles in inflammatory bowel disease, intestinal cancer, and other diseases are summarized inductively. In addition, the mechanism of action of nanomedicines in repairing mucosa, inhibiting inflammation, and alleviating the disease process is also discussed. Through such systematic elaboration, it offers a basis for nanomaterials to help advance in vitro research on the intestine and provide precision treatments in the clinic.
登录
查看更多内容
影响因子：
158.5
作者：
Cristofanilli, M;Budd, GT;Hayes, DF
通讯作者：
Hayes, DF
影响因子：
10.2
作者：
Cohen S;Margel S
通讯作者：
Margel S
影响因子：
17.1
作者：
Bao, Lin;Cui, Xuejing;Chen, Chunying
通讯作者：
Chen, Chunying
DOI：
10.3390/bios11020055
发表时间：
2021-02-20
期刊：
Biosensors
影响因子：
--
作者：
Barani M;Mukhtar M;Rahdar A;Sargazi S;Pandey S;Kang M
通讯作者：
Kang M
用于骨组织工程的微孔甲基丙烯酸乙二醇壳聚糖-蒙脱石纳米复合水凝胶
影响因子：
16.6
作者：
Cui, Zhong-Kai;Kim, Soyon;Lee, Min
通讯作者：
Lee, Min