Step‐Gradient Composite Hydrogels for Local Drug Delivery and Directed Cell Migration
Step‐Gradient Composite Hydrogels for Local Drug Delivery and Directed Cell Migration
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用于局部药物输送和定向细胞迁移的Stepâ梯度复合水凝胶
DOI：
10.1002/anbr.202000114
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发表时间：
2021
影响因子：
3.4
通讯作者：
N. S. Kehr
中科院分区：
文献类型：
--
作者：
A. Motealleh;N. S. Kehr
尽管近几十年来生物医学工程取得了显着的进步，但作为人工组织构建体的人造生物材料仍然有改进的空间，并且需要同时提供几种特性。具体而言，工程生物材料应具有机械、生物化学和地形梯度、3D网络、孔隙率、生物相容性、生物降解性和可注射性以及局部递送药物、模拟细胞外基质环境、控制定向细胞迁移、促进植入组织构建物的血管化、抑制植入后的炎症、并且以微创方式植入。在这方面，创建了通过3D生物打印技术制造的新的阶梯梯度复合水凝胶和支架（GradGA）。该GradGA材料使用不同比例的多功能多孔纳米材料（NM）、藻酸盐和甲基丙烯酰明胶构建，其中多功能NM允许抗炎和化疗药物分子在复合水凝胶的3D网络内持续和pH响应受控释放。此外，该结构促进健康细胞活力和在GradGA的XY平面中的迁移，而由于化疗药物分子的pH响应性释放，它减少了癌细胞的迁移和生长。
Even though remarkable advances in biomedical engineering have been made in recent decades, fabricated biomaterials as artificial tissue constructs still have room for improvement and need to offer several characteristics simultaneously. Specifically, engineered biomaterials should possess mechanical, biochemical, and topographical gradients, a 3D network, porosity, biocompatibility, biodegradability, and injectability as well as the ability to deliver drugs locally, to mimic the extracellular matrix environment, to control directional cell migration, to promote vascularization of implanted tissue constructs, to inhibit inflammation after implantation, and to be implanted in a minimally invasive manner. In this respect, a new step‐gradient composite hydrogel and scaffold (GradGA) fabricated by a 3D bioprinting technique is created. This GradGA material is constructed using different ratios of multifunctional porous nanomaterials (NMs), alginate, and gelatin methacryloyl, where the multifunctional NMs allowed for sustained and pH‐responsive controlled release of anti‐inflammatory and chemotherapeutic drug molecules within the 3D network of the composite hydrogel. Further, the construction promotes healthy cell viability and migration in theXYplane of GradGA, whereas it reduces the migration and growth of cancer cells due to the pH‐responsive release of chemotherapeutic drug molecules.
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影响因子：
14
作者：
Nichol, Jason W.;Koshy, Sandeep T.;Bae, Hojae;Hwang, Chang M.;Yamanlar, Seda;Khademhosseini, Ali
通讯作者：
Khademhosseini, Ali
DOI：
10.1016/j.nano.2017.02.022
发表时间：
2018-10
期刊：
Nanomedicine : nanotechnology, biology, and medicine
影响因子：
--
作者：
Cross LM;Shah K;Palani S;Peak CW;Gaharwar AK
通讯作者：
Gaharwar AK
有机分子从多孔载体到粘附细胞的表面介导刺激响应传递
影响因子：
10
作者：
B. Ergün;L. De Cola;H. Franke;N. S. Kehr
通讯作者：
N. S. Kehr
DOI：
10.1073/pnas.0908401107
发表时间：
2010-03-02
影响因子：
11.1
作者：
Al-Jamal, Khuloud T.;Al-Jamal, Wafa' T.;Kostarelos, Kostas
通讯作者：
Kostarelos, Kostas
影响因子：
9.7
作者：
Cheng H;Chabok R;Guan X;Chawla A;Li Y;Khademhosseini A;Jang HL
通讯作者：
Jang HL