Muscularis macrophages: Key players in intestinal homeostasis and disease.
Muscularis macrophages: Key players in intestinal homeostasis and disease.
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DOI：
10.1016/j.cellimm.2017.12.009
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发表时间：
2018-08
影响因子：
4.3
通讯作者：
Boeckxstaens GE
中科院分区：
文献类型：
--
作者：
De Schepper S;Stakenborg N;Matteoli G;Verheijden S;Boeckxstaens GE
肌层巨噬细胞密集地定殖在胃肠道的最外层。肌层巨噬细胞与肠神经元双向通讯。肌层巨噬细胞具有组织保护作用，但可能导致疾病。目前的挑战是破译肌层巨噬细胞的治疗潜力。驻留在胃肠道外肌层中的巨噬细胞是高度特化的细胞，其对于稳态条件期间以及疾病期间的组织稳态是必不可少的。它们的特征在于其独特的保护功能表型，这无疑是与其环境（包括肠神经系统）相互作用的结果。这种肌层巨噬细胞-神经元相互作用决定了肠运动并促进损伤和感染期间的组织保护，但也可能导致胃肠道疾病如术后肠梗阻和胃轻瘫中的组织损伤。虽然肌层巨噬细胞的重要性已被清楚地认识到，但这些细胞的不同方面仍在很大程度上未被探索，例如它们的起源，寿命和决定其功能和表型的指导性信号。在这篇综述中，我们将讨论的表型，功能和起源的肌层巨噬细胞在稳态和疾病条件。我们将强调与神经元的双向串扰和潜在的治疗策略，靶向和操纵肌层巨噬细胞以恢复其作为疾病治疗的保护性特征。
Muscularis macrophages densily colonize the outermost layer of the gastrointestinal tract. Muscularis macrophages communicate with enteric neurons in a bidirectional matter. Muscularis macrophages are tissue-protective but can contribute to disease. Current challenges are to decipher therapeutic potentials of muscularis macrophages. Macrophages residing in the muscularis externa of the gastrointestinal tract are highly specialized cells that are essential for tissue homeostasis during steady-state conditions as well as during disease. They are characterized by their unique protective functional phenotype that is undoubtedly a consequence of the reciprocal interaction with their environment, including the enteric nervous system. This muscularis macrophage-neuron interaction dictates intestinal motility and promotes tissue-protection during injury and infection, but can also contribute to tissue damage in gastrointestinal disorders such as post-operative ileus and gastroparesis. Although the importance of muscularis macrophages is clearly recognized, different aspects of these cells remain largely unexplored such their origin, longevity and instructive signals that determine their function and phenotype. In this review, we will discuss the phenotype, functions and origin of muscularis macrophages during steady-state and disease conditions. We will highlight the bidirectional crosstalk with neurons and potential therapeutic strategies that target and manipulate muscularis macrophages to restore their protective signature as a treatment for disease.
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影响因子：
6.7
作者：
通讯作者：
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影响因子：
3.5
作者：
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DOI：
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影响因子：
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作者：
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影响因子：
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作者：
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