Exploring the Roles of lncRNAs in GBM Pathophysiology and Their Therapeutic Potential.
Exploring the Roles of lncRNAs in GBM Pathophysiology and Their Therapeutic Potential.
复制标题
DOI：
10.3390/cells9112369
复制
发表时间：
2020-10-28
期刊：
影响因子：
6
通讯作者：
Willey CD
中科院分区：
文献类型：
--
作者：
Stackhouse CT;Gillespie GY;Willey CD
胶质母细胞瘤（GBM）仍然是最具破坏性的原发性中枢神经系统恶性肿瘤，中位生存期约为15个月。过去几十年的研究并没有在治疗GBM方面取得重大进展。与此同时，一类新的分子，长链非编码rna (lncRNAs)，被发现在癌症和正常生物学中发挥着多种作用。下一代测序技术的日益普及和lncRNA特异性微阵列的出现促进了lncRNA病因学的研究。分子和计算方法可用于预测lncRNA的功能。LncRNAs可以作为分子诱饵、支架、超级增强子或抑制子。这些分子可以在表达和/或表观遗传水平上作为GBM细胞的表型开关。lncrna可以影响干性/分化、增殖、侵袭、存活、DNA损伤反应和染色质动力学。这些转录物的异常表达可能促进治疗抵抗，导致肿瘤复发。lncrna可以作为GBM和其他癌症的新的治疗诊断或预后生物标志物。基于rna的治疗方法也可用于靶向lncrna，作为治疗原发性或复发性GBM的新途径。在这篇综述中，我们探讨了lncrna在GBM病理生理中的作用，并提出了它们治疗GBM的新潜力。
Glioblastoma (GBM) remains the most devastating primary central nervous system malignancy with a median survival of around 15 months. The past decades of research have not yielded significant advancements in the treatment of GBM. In that same time, a novel class of molecules, long non-coding RNAs (lncRNAs), has been found to play a multitude of roles in cancer and normal biology. The increased accessibility of next generation sequencing technologies and the advent of lncRNA-specific microarrays have facilitated the study of lncRNA etiology. Molecular and computational methods can be applied to predict lncRNA function. LncRNAs can serve as molecular decoys, scaffolds, super-enhancers, or repressors. These molecules can serve as phenotypic switches for GBM cells at the expression and/or epigenetic levels. LncRNAs can affect stemness/differentiation, proliferation, invasion, survival, DNA damage response, and chromatin dynamics. Aberrant expression of these transcripts may facilitate therapy resistance, leading to tumor recurrence. LncRNAs could serve as novel theragnostic or prognostic biomarkers in GBM and other cancers. RNA-based therapeutics may also be employed to target lncRNAs as a novel route of treatment for primary or recurrent GBM. In this review, we explore the roles of lncRNAs in GBM pathophysiology and posit their novel therapeutic potential for GBM.
登录
查看更多内容
影响因子：
4
作者：
Cai T;Liu Y;Xiao J
通讯作者：
Xiao J
影响因子：
29.4
作者：
Chen B;Dragomir MP;Fabris L;Bayraktar R;Knutsen E;Liu X;Tang C;Li Y;Shimura T;Ivkovic TC;De Los Santos MC;Anfossi S;Shimizu M;Shah MY;Ling H;Shen P;Multani AS;Pardini B;Burks JK;Katayama H;Reineke LC;Huo L;Syed M;Song S;Ferracin M;Oki E;Fromm B;Ivan C;Bhuvaneshwar K;Gusev Y;Mimori K;Menter D;Sen S;Matsuyama T;Uetake H;Vasilescu C;Kopetz S;Parker-Thornburg J;Taguchi A;Hanash SM;Girnita L;Slaby O;Goel A;Varani G;Gagea M;Li C;Ajani JA;Calin GA
通讯作者：
Calin GA
影响因子：
3.1
作者：
Gao Y;Xu Y;Wang J;Yang X;Wen L;Feng J
通讯作者：
Feng J
影响因子：
--
作者：
Brodie S;Lee HK;Jiang W;Cazacu S;Xiang C;Poisson LM;Datta I;Kalkanis S;Ginsberg D;Brodie C
通讯作者：
Brodie C
影响因子：
4.3
作者：
Guglas, Kacper;Kolenda, Tomasz;Lamperska, Katarzyna
通讯作者：
Lamperska, Katarzyna