Effect of booster blood transfusions on oxygen utilization in infants with bronchopulmonary dysplasia.
Effect of booster blood transfusions on oxygen utilization in infants with bronchopulmonary dysplasia.
复制标题
加强输血对支气管肺发育不良婴儿氧利用的影响。
DOI：
10.1016/s0022-3476(88)80389-5
复制
发表时间：
1988
期刊：
影响因子：
--
通讯作者：
Cohen,RS
中科院分区：
文献类型：
--
作者：
Alverson,DC;Isken,VH;Cohen,RS
为了评估加强输血对支气管肺发育不良婴儿氧利用率的影响，我们在10例氧依赖性支气管肺发育不良婴儿输血治疗前和治疗后24小时无创测量了耗氧量（Vo 2）和全身氧转运（SOT）变量。婴儿出生时的平均胎龄为27.6周，平均出生体重为0.88 kg。研究体重平均为1.24±0.35 kg，研究年龄平均为5.5±2.4周。吸入氧浓度分数的要求平均为0.41±0.15，以保持氧饱和度为0.93±0.02。通过市售的分析仪通过流通回路和连接到罩或与呼吸机成一直线的泵来测量Vo 2。通过脉冲多普勒超声测量心输出量。通过经皮脉搏血氧仪测量氧饱和度。氧利用系数计算为Vo 2/SOT。输血由浓缩的红细胞（10 ml/kg）组成。输血后所有受试者的氧利用率均下降（p<0.01），但氧利用率系数较高的受试者的氧利用率下降幅度更大（r=-0.80，p <0.01），这表明在特定患者中，特别是在氧利用率较高的患者中，存在生理益处。全身氧转运也显著增加（p<0.01），Vo 2降低（p<0.02）。血红蛋白水平单独与全身氧转运、Vo 2或输血前氧利用水平无关，因此不能预测哪些受试者会从输血中获得生理学益处，如氧利用率福尔斯下降所反映的。
To assess the impact of booster transfusions on oxygen utilization in infants with bronchopulmonary dysplasia, we noninvasively measured oxygen consumption (Vo2) and the variables of systemic oxygen transport (SOT) before and 24 hours after transfusion therapy in 10 oxygen-dependent infants with bronchopulmonary dysplasia. The infants had been born with a mean gestational age of 27.6 weeks and a mean birth weight of 0.88 kg. Study weight averaged 1.24±0.35 kg, and study age averaged 5.5±2.4 weeks. Requirements for fractional concentration of inspired oxygen averaged 0.41±0.15 to maintain an oxygen saturation of 0.93±0.02. The Vo2was measured by means of a commercially availabie analyzer through a flow-through circuit and pump connected to a hood or in line with the ventilator. Cardiac output was calculated by means of pulsed Doppler ultrasonography. Oxygen saturation was measured by means of transcutaneous pulse oximetry. The coefficient of oxygen utilization was calculated as Vo2/SOT. Transfusion consisted of packed erythrocytes (10 ml/kg). Oxygen utilization fell in all subjects after transfusion (p<0.01), but it fell more substantially in subjects with higher coefficients of oxygen utilization (r=−0.80,p<0.01), suggesting a physiologic benefit in selected patients, particularly those with higher levels of oxygen utilization. There was also a significant increase in overall systemic oxygen transport (p<0.01) and decrease in Vo2(p<0.02). Hemoglobin levels alone did not correlate with overall systemic oxygen transport, Vo2, or level of oxygen use before transfusion, and thus did not predict which subjects would have a physiologic benefit from transfusion as refiected by falls in oxygen utilization.
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DOI：
--
发表时间：
1974
期刊：
影响因子：
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作者：
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DOI：
--
发表时间：
1982
期刊：
The Medical clinics of North America
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