Effect of wheat bran derived prebiotic supplementation on gastrointestinal transit, gut microbiota, and metabolic health: a randomized controlled trial in healthy adults with a slow gut transit.
Effect of wheat bran derived prebiotic supplementation on gastrointestinal transit, gut microbiota, and metabolic health: a randomized controlled trial in healthy adults with a slow gut transit.
复制标题
DOI：
10.1080/19490976.2019.1704141
复制
发表时间：
2020-11-09
期刊：
影响因子：
12.2
通讯作者：
Blaak EE
中科院分区：
文献类型：
--
作者：
Müller M;Hermes GDA;Emanuel E C;Holst JJ;Zoetendal EG;Smidt H;Troost F;Schaap FG;Damink SO;Jocken JWE;Lenaerts K;Masclee AAM;Blaak EE
急性摄入麦麸提取物阿拉伯低聚糖（AXOS）可调节肠道微生物群，改善健康人的粪便特征和餐后排便。然而，人们对长期摄入AXOS如何影响胃肠道功能、肠道微生物群和代谢健康知之甚少。在这项随机、安慰剂对照、双盲研究中，我们评估了AXOS摄入对胃肠传输缓慢但无便秘的成年人的胃肠功能和代谢健康的影响。48名血糖正常的成年人被纳入研究，全肠通过时间（WGTT）> 35小时，接受15 g/天AXOS或安慰剂治疗主要结果是WGTT，次要结果包括粪便参数、肠道通透性、短链脂肪酸（SCFA）、微生物群组成、能量消耗、底物氧化、葡萄糖、胰岛素、脂质、肠道激素、和脂肪组织（AT）功能。WGTT无变化，但AXOS后粪便硬度变软。12-AXOS摄入量增加了双歧杆菌，减少了微生物α多样性，从而显著改变了微生物群。在良好的分类准确性下，总体微生物群组成将AXOS后WGTT降低的应答者分类。与安慰剂相比，AXOS后肠促胰岛素激素胰高血糖素样蛋白1降低。能量消耗、血浆代谢物、AT参数、SCFA和肠道通透性均无变化。总之，麦麸提取物的摄入增加了粪便双歧杆菌和软化粪便的一致性，而对具有缓慢GI传输的健康人的能量代谢没有重大影响。我们表明，总体肠道微生物群将AXOS后WGTT降低的应答者分类，强调GI转运及其变化与肠道微生物群相关，不依赖于双歧杆菌。NCT02491125
Acute intake of the wheat bran extract Arabinoxylan-Oligosaccharide (AXOS) modulates the gut microbiota, improves stool characteristics and postprandial glycemia in healthy humans. Yet, little is known on how long-term AXOS intake influences gastrointestinal (GI) functioning, gut microbiota, and metabolic health. In this randomized, placebo-controlled, double-blind study, we evaluated the effects of AXOS intake on GI function and metabolic health in adults with slow GI transit without constipation. Forty-eight normoglycemic adults were included with whole-gut transit time (WGTT) of >35 h receiving either 15 g/day AXOS or placebo (maltodextrin) for 12-wks. The primary outcome was WGTT, and secondary outcomes included stool parameters, gut permeability, short-chain fatty acids (SCFA), microbiota composition, energy expenditure, substrate oxidation, glucose, insulin, lipids, gut hormones, and adipose tissue (AT) function. WGTT was unchanged, but stool consistency softened after AXOS. 12-wks of AXOS intake significantly changed the microbiota by increasing Bifidobacterium and decreasing microbial alpha-diversity. With a good classification accuracy, overall microbiota composition classified responders with decreased WGTT after AXOS. The incretin hormone Glucagon-like protein 1 was reduced after AXOS compared to placebo. Energy expenditure, plasma metabolites, AT parameters, SCFA, and gut permeability were unchanged. In conclusion, intake of wheat bran extract increases fecal Bifidobacterium and softens stool consistency without major effects on energy metabolism in healthy humans with a slow GI transit. We show that overall gut microbiota classified responders with decreased WGTT after AXOS highlighting that GI transit and change thereof were associated with gut microbiota independent of Bifidobacterium. NCT02491125
登录
查看更多内容
糖尿病的医疗标准 - 2010年。
影响因子：
16.2
作者：
American Diabetes Association
通讯作者：
American Diabetes Association
影响因子：
7.1
作者：
Cummings, JH;Macfarlane, GT;Englyst, HN
通讯作者：
Englyst, HN
影响因子：
3.6
作者：
Clegg, Miriam;Shafat, Amir
通讯作者：
Shafat, Amir
影响因子：
5
作者：
Boll, Elin V. Johansson;Ekstrom, Linda M. N. K.;Ostman, Elin M.
通讯作者：
Ostman, Elin M.
DOI：
10.1073/pnas.1000080107
发表时间：
2011-03-15
影响因子：
11.1
作者：
Caporaso, J. Gregory;Lauber, Christian L.;Knight, Rob
通讯作者：
Knight, Rob