Newborn cortical neurons: only for neonates?

Newborn cortical neurons: only for neonates?
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新生儿皮质神经元:仅适用于新生儿?

DOI:
10.1016/j.tins.2012.09.004
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发表时间:
2013-01
影响因子:
15.9
通讯作者:
Bordey A
Bordey A
中科院分区:
医学1区
文献类型:
--
作者:
Feliciano DM;Bordey A

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尽管关于成人皮质神经发生的存在存在一个世纪的争论,但尚未达成共识。在这里,我们回顾了成人和新生儿大脑皮层神经元的存在、起源、迁移和整合的证据。我们发现,缺乏共识可能源于已观察到的出生后皮质神经发生率较低,事实上它可能仅限于中间神经元的亚型,以及其他条件(生理和环境)的可变性。我们强调,神经发生发生在新生儿皮质中,神经干细胞存在于成年期;也许这些祖细胞处于休眠状态,但它们可能会被重新激活,例如,由于受伤。
Despite a century of debate over the existence of adult cortical neurogenesis, a consensus has not yet been reached. Here, we review evidence of the existence, origin, migration, and integration of neurons into the adult and neonatal cerebral cortex. We find that the lack of consensus likely stems from the low rate of postnatal cortical neurogenesis that has been observed, the fact that it may be limited to sub-types of interneurons, and variability in other conditions, both physiological and environmental. We emphasize that neurogenesis occurs in the neonatal cortex and neural stem cells exist into adulthood; perhaps these progenitors are dormant, but they may be reactivated, for example, with injury.
DOI: 10.1007/s00441-011-1200-z
发表时间: 2011-07
影响因子: 3.6
作者:
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