Brain regions responsible for tinnitus distress and loudness: a resting-state FMRI study.
Brain regions responsible for tinnitus distress and loudness: a resting-state FMRI study.
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DOI：
10.1371/journal.pone.0067778
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发表时间：
2013
期刊：
影响因子：
3.7
通讯作者：
Kaneoke Y
中科院分区：
文献类型：
--
作者：
Ueyama T;Donishi T;Ukai S;Ikeda Y;Hotomi M;Yamanaka N;Shinosaki K;Terada M;Kaneoke Y
主观性耳鸣的特征是在没有外部听觉刺激的情况下感知幻觉声音。我们假设中枢神经系统中的异常功能连接区域可能是慢性主观性耳鸣的病理生理学基础。功能连接性(FC)强度的统计意义受区域自相关系数(AC)的影响。在这项研究中，我们使用静息状态功能磁共振成像(FMRI)和测量区域平均FC强度(一个区域与所有其他区域之间的平均互相关系数，不考虑AC(RGC)和考虑AC(RGCA)的影响)来阐明与耳鸣症状相关的脑区，如痛苦、抑郁和响亮。与以前的研究一致，耳鸣的响度与耳鸣相关的痛苦和抑郁状态无关。虽然RGC和RGCA都显示出与耳鸣相关症状有统计学意义关系的相似的大脑区域，但RGCA的区域更局部化，更清楚地描绘出与每种症状特定相关的区域。双侧直肌回的RGCA值与抑郁状态呈正相关，双侧扣带回前、中回的RGCA值与抑郁状态呈负相关。双侧丘脑、双侧海马体和左侧尾状回的RGCA值与耳鸣响度呈正相关，左侧额上回和左侧扣带回的RGCA值与耳鸣响度呈负相关。这些结果表明，耳鸣症状与不同的大脑区域有关。痛苦和抑郁状态的区域已知与抑郁有关，而耳鸣响度的区域已知与默认模式网络和多感觉信息的整合有关。
Subjective tinnitus is characterized by the perception of phantom sound without an external auditory stimulus. We hypothesized that abnormal functionally connected regions in the central nervous system might underlie the pathophysiology of chronic subjective tinnitus. Statistical significance of functional connectivity (FC) strength is affected by the regional autocorrelation coefficient (AC). In this study, we used resting-state functional MRI (fMRI) and measured regional mean FC strength (mean cross-correlation coefficient between a region and all other regions without taking into account the effect of AC (rGC) and with taking into account the effect of AC (rGCa) to elucidate brain regions related to tinnitus symptoms such as distress, depression and loudness. Consistent with previous studies, tinnitus loudness was not related to tinnitus-related distress and depressive state. Although both rGC and rGCa revealed similar brain regions where the values showed a statistically significant relationship with tinnitus-related symptoms, the regions for rGCa were more localized and more clearly delineated the regions related specifically to each symptom. The rGCa values in the bilateral rectus gyri were positively correlated and those in the bilateral anterior and middle cingulate gyri were negatively correlated with distress and depressive state. The rGCa values in the bilateral thalamus, the bilateral hippocampus, and the left caudate were positively correlated and those in the left medial superior frontal gyrus and the left posterior cingulate gyrus were negatively correlated with tinnitus loudness. These results suggest that distinct brain regions are responsible for tinnitus symptoms. The regions for distress and depressive state are known to be related to depression, while the regions for tinnitus loudness are known to be related to the default mode network and integration of multi-sensory information.
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影响因子：
3.7
作者：
Husain FT;Pajor NM;Smith JF;Kim HJ;Rudy S;Zalewski C;Brewer C;Horwitz B
通讯作者：
Horwitz B
影响因子：
4.7
作者：
Fujii K;Nagata C;Nakamura K;Kawachi T;Takatsuka N;Oba S;Shimizu H
通讯作者：
Shimizu H
DOI：
10.3109/03005368909077819
发表时间：
1989-01-01
期刊：
British Journal of Audiology
影响因子：
--
作者：
AXELSSON A;RINGDAHL A
通讯作者：
RINGDAHL A
影响因子：
1.6
作者：
Hiller, Wolfgang;Goebel, Gerhard
通讯作者：
Goebel, Gerhard
影响因子：
3.3
作者：
Cheung, S. W.;Larson, P. S.
通讯作者：
Larson, P. S.