Discrimination task reveals differences in neural bases of tinnitus and hearing impairment.
Discrimination task reveals differences in neural bases of tinnitus and hearing impairment.
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DOI：
10.1371/journal.pone.0026639
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发表时间：
2011
期刊：
影响因子：
3.7
通讯作者：
Horwitz B
中科院分区：
文献类型：
--
作者：
Husain FT;Pajor NM;Smith JF;Kim HJ;Rudy S;Zalewski C;Brewer C;Horwitz B
我们使用功能性磁共振成像（fMRI）研究了慢性耳鸣或听力损失患者的听觉感知和认知过程。我们的参与者分为三组：双侧听力损失和耳鸣（TIN），双侧听力损失无耳鸣（HL），听力正常无耳鸣（NH）。我们采用纯音和调频扫频作为两个任务的刺激：被动听和主动辨别。所有受试者在2 kHz范围内听力正常，所有刺激都在2 kHz下进行低通滤波，以便所有参与者都能同样好地听到它们。所有三个组的歧视任务的表现是相似的。在所有参与者中，包括初级和非初级听觉皮层在内的一组分布式大脑区域对这两项任务的反应都比休息时更大。直接比较两组，我们发现与HL组相比，耳鸣参与者的顶叶和额叶激活减少，额叶的反应相对于NH组减少。此外，相对于NH组，HL受试者的前扣带回反应增加。我们的研究结果表明，一个假定的听觉注意力和短期记忆网络，包括在额叶，顶叶和颞叶皮层和前扣带回的区域的差异参与，可能是一个关键的差异，慢性耳鸣伴随听力损失相对于听力损失的神经基础。
We investigated auditory perception and cognitive processing in individuals with chronic tinnitus or hearing loss using functional magnetic resonance imaging (fMRI). Our participants belonged to one of three groups: bilateral hearing loss and tinnitus (TIN), bilateral hearing loss without tinnitus (HL), and normal hearing without tinnitus (NH). We employed pure tones and frequency-modulated sweeps as stimuli in two tasks: passive listening and active discrimination. All subjects had normal hearing through 2 kHz and all stimuli were low-pass filtered at 2 kHz so that all participants could hear them equally well. Performance was similar among all three groups for the discrimination task. In all participants, a distributed set of brain regions including the primary and non-primary auditory cortices showed greater response for both tasks compared to rest. Comparing the groups directly, we found decreased activation in the parietal and frontal lobes in the participants with tinnitus compared to the HL group and decreased response in the frontal lobes relative to the NH group. Additionally, the HL subjects exhibited increased response in the anterior cingulate relative to the NH group. Our results suggest that a differential engagement of a putative auditory attention and short-term memory network, comprising regions in the frontal, parietal and temporal cortices and the anterior cingulate, may represent a key difference in the neural bases of chronic tinnitus accompanied by hearing loss relative to hearing loss alone.
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发表时间：
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