Investigating lymphangiogenesis in a sacrificially bioprinted volumetric model of breast tumor tissue.
Investigating lymphangiogenesis in a sacrificially bioprinted volumetric model of breast tumor tissue.
复制标题
在乳腺肿瘤组织的生物打印体积模型中研究淋巴管生成。
DOI：
10.1016/j.ymeth.2020.04.003
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发表时间：
2021-06
期刊：
影响因子：
--
通讯作者：
Zhang YS
中科院分区：
文献类型：
--
作者：
Liu T;Liu Q;Anaya I;Huang D;Kong W;Mille LS;Zhang YS
淋巴管作为转移的一种手段，在其进展过程中经常被肿瘤组织募集。然而，仍然迫切需要可靠的体外模型来剖析淋巴管和肿瘤之间复杂的串扰。在这里，我们描述了一种基于牺牲生物打印的组织工程方法，以开发具有封装的多尺度淋巴管的人乳腺肿瘤的使能模型，该模型与现有的显微镜兼容，以检查淋巴管发芽和乳腺肿瘤细胞在生理相关的体积微环境中迁移的过程。该平台将有助于阐明肿瘤微环境、肿瘤淋巴管生成、淋巴转移以及未来肿瘤抗淋巴管生成治疗的复杂生物学。我们还预计该方法将广泛用于生产各种组织及其模型，并将血管移植到相关应用中。
Lymphatic vessels, as a means to metastasize, are frequently recruited by tumor tissues during their progression. However, reliable in vitro models to dissect the intricate crosstalk between lymphatic vessels and tumors are still in urgent demand. Here, we describe a tissue- engineering method based on sacrificial bioprinting, to develop an enabling model of the human breast tumor with encapsulated multiscale lymphatic vessels, which is compatible with existing microscopy to examine the processes of lymphatic vessel sprouting and breast tumor cell migration in a physiologically relevant volumetric microenvironment. This platform will potentially help shed light on the complex biology of the tumor microenvironment, tumor lymphangiogenesis, lymphatic metastasis, as well as tumor anti-lymphangiogenic therapy in the future. We further anticipate wide adoption of the method to the production of various tissues and their models with incorporation of lymphatics vessels towards relevant applications.
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影响因子：
254.7
作者：
Jemal, Ahmedin;Siegel, Rebecca;Thun, Michael J.
通讯作者：
Thun, Michael J.
影响因子：
17.1
作者：
Fankhauser, Manuel;Broggi, Maria A. S.;Swartz, Melody A.
通讯作者：
Swartz, Melody A.
DOI：
10.1196/annals.1413.020
发表时间：
2008-01-01
期刊：
LYMPHATIC CONTINUUM REVISITED
影响因子：
--
作者：
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通讯作者：
Stacker, Steven A.
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影响因子：
16.6
作者：
Gong, Jiaxing;Schuurmans, Carl C. L.;Zhang, Yu Shrike
通讯作者：
Zhang, Yu Shrike
影响因子：
29.4
作者：
Hansen, Christopher J.;Saksena, Rajat;Lewis, Jennifer A.
通讯作者：
Lewis, Jennifer A.