Reliability of triclosan measures in repeated urine samples from Norwegian pregnant women.
Reliability of triclosan measures in repeated urine samples from Norwegian pregnant women.
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DOI：
10.1038/jes.2013.95
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发表时间：
2014-09
影响因子：
4.5
通讯作者：
中科院分区：
文献类型：
--
作者：
三氯生(TCS)是一种用于个人护理产品的合成抗菌化学物质，可在尿液中检测到。在挪威和美国，尿液中的TCS与儿童过敏有关。据报道，在美国儿童和波多黎各孕妇中，TCS尿液浓度的时间可靠性达到了合理的程度。我们检查了挪威孕妇尿液中TCS检测的可靠性。在2007年和2008年参加挪威母婴队列研究(MOBA)的45名妇女中，在怀孕17周、23周和29周收集的现场尿样中检测了三氯生。计算Spearman等级相关系数(Rs)和组内相关系数(ICC)统计量。在45名妇女中，56%的人至少有一份样本的检测值超过了方法限值(2.3ug/L)。17周和23周TCS浓度的相关系数为0.61，17周和29周浓度的相关系数为0.49。对于这三个时间点，ICC为0.49。挪威孕妇重复尿样中TCS浓度的可靠性相当好，这表明单一尿样可以充分反映怀孕期间TCS的暴露情况。
Triclosan (TCS) is a synthetic antibacterial chemical that is used in personal care products and is measurable in urine. Urinary TCS has been associated with allergy in children in Norway and the United States. A reasonable degree of temporal reliability of TCS urinary concentrations has been reported among U.S. children as well as for Puerto Rican pregnant women. We examined the reliability of TCS measures in urine among Norwegian pregnant women. Triclosan was measured in spot urine samples collected in gestational weeks 17, 23, and 29 from 45 women in The Norwegian Mother and Child Cohort Study (MoBa) enrolled in 2007 and 2008. Spearman’s rank correlation coefficient (rs) and intraclass correlation coefficient (ICC) statistics were calculated. Fifty-six percent of the 45 women had a least one sample with a value above the method limit of detection (2.3 µg/L). The correlation coefficients were 0.61 for TCS concentrations at 17 and 23 weeks and 0.49 for concentrations at 17 and 29 weeks. For the three time points, the ICC was 0.49. The reliability of TCS concentrations in repeated urine samples from pregnant Norwegian women was reasonably good, suggesting a single urine sample can adequately represent TCS exposure during pregnancy.
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DOI：
10.1097/ede.0b013e3181ce97d8
发表时间：
2010-07
期刊：
Epidemiology (Cambridge, Mass.)
影响因子：
--
作者：
Nie L;Chu H;Liu C;Cole SR;Vexler A;Schisterman EF
通讯作者：
Schisterman EF
影响因子：
8.3
作者：
Lassen, Tina Harmer;Frederiksen, Hanne;Andersson, Anna-Maria
通讯作者：
Andersson, Anna-Maria
影响因子：
10.4
作者：
Calafat AM;Ye X;Wong LY;Reidy JA;Needham LL
通讯作者：
Needham LL
影响因子：
14.2
作者：
Savage, Jessica H.;Matsui, Elizabeth C.;Wood, Robert A.;Keet, Corinne A.
通讯作者：
Keet, Corinne A.
DOI：
10.1080/15287390600631706
发表时间：
2006-10-15
影响因子：
2.6
作者：
Sandborgh-Englund, Gunilla;Adolfsson-Erici, Margaretha;Ekstrand, Jan
通讯作者：
Ekstrand, Jan