Urinary levels of triclosan and parabens are associated with aeroallergen and food sensitization.
Urinary levels of triclosan and parabens are associated with aeroallergen and food sensitization.
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DOI：
10.1016/j.jaci.2012.05.006
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发表时间：
2012-08
影响因子：
14.2
通讯作者：
Keet, Corinne A.
中科院分区：
文献类型：
--
作者：
Savage, Jessica H.;Matsui, Elizabeth C.;Wood, Robert A.;Keet, Corinne A.
关键词：
内分泌干扰化合物（EDCs）具有免疫调节作用。我们感兴趣的是确定它们与过敏性致敏的关系。确定内分泌干扰物与过敏性致敏之间的关系，以及这种关系是否取决于内分泌干扰物的抗菌特性和/或性别。数据来自2005-2006年全国健康和营养检查调查，其中860名儿童的尿双酚A、三氯生、二苯甲酮-3、对羟基苯甲酸丙酯、甲酯、丁酯和乙酯以及特异性IgE。空气过敏原和食物致敏定义为对空气过敏原或食物至少有一种阳性（≥0.35 kU/L）特异性IgE。使用逻辑回归来确定内分泌干扰物与致敏作用的相关性。分析调整了尿肌酐、年龄、种族和贫困指数比。空气过敏原致敏的几率随着抗微生物内分泌干扰物三氯生和对羟基苯甲酸丙酯和丁酯的水平而显著增加（p≤0.04）。在男性受试者中，食物致敏的几率随着尿三氯生水平的增加而显著增加（第三与第一三分位数的比值比为3.9，趋势p=0.02）。性别和三氯生之间存在显著的相互作用，男性更可能因暴露而对食物敏感（p=0.03）。对于非抗菌性内分泌干扰物双酚A和二苯甲酮-3，没有发现类似的关联（p>0.2）。作为一个群体，内分泌干扰物与过敏原致敏无关。然而，抗微生物内分泌干扰物三氯生和对羟基苯甲酸酯的水平与过敏性致敏显著相关。抗微生物内分泌干扰物在过敏性疾病中的潜在作用值得进一步研究，因为它们在西方社会中普遍使用。
Endocrine-disrupting compounds (EDCs) have immune-modulating effects. We were interested in determining their association with allergic sensitization. To determine the association between EDCs and allergic sensitization and if this relationship depended on the antimicrobial properties of the EDCs and/or gender. Data were obtained from the 2005–2006 National Health and Nutrition Examination Survey in which urinary bisphenol A, triclosan, benzophenone-3, and propyl, methyl, butyl and ethyl paraben, and specific IgE were available on 860 children. Aeroallergen and food sensitization were defined as having at least one positive (≥0.35 kU/L) specific IgE to an aeroallergen or a food. Logistic regression was used to determine the association of EDCs and sensitization. Analyses were adjusted for urinary creatinine, age, ethnicity, and poverty index ratio. The odds of aeroallergen sensitization significantly increased with the level of the antimicrobial EDCs triclosan and propyl and butyl paraben (p≤0.04). The odds of food sensitization significantly increased with the level of urinary triclosan among male subjects (odds ratio for 3rd versus 1st tertile 3.9, p=0.02 for trend). There was a significant interaction between gender and triclosan, with males being more likely to be food sensitized with exposure (p=0.03). Similar associations were not identified for the non-antimicrobial EDCs bisphenol A and benzophenone-3 (p>0.2). As a group, EDCs are not associated with allergen sensitization. However, levels of the antimicrobial EDCs triclosan and parabens were significantly associated with allergic sensitization. The potential role of antimicrobial EDCs in allergic disease warrants further study as they are commonly used in Western society.
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影响因子：
14.2
作者：
Gergen, Peter J.;Arbes, Samuel J., Jr.;Calatroni, Agustin;Mitchell, Herman E.;Zeldin, Darryl C.
通讯作者：
Zeldin, Darryl C.
影响因子：
4.3
作者：
Crofton, Kevin M.;Paul, Katie B.;Hedge, Joan M.
通讯作者：
Hedge, Joan M.
影响因子：
6.7
作者：
Mustafa, M;Bakhiet, M;Modéer, T
通讯作者：
Modéer, T
Bisphenol A和Triclosan对美国人口免疫参数的影响，NHANES 2003-2006。
影响因子：
10.4
作者：
Clayton EM;Todd M;Dowd JB;Aiello AE
通讯作者：
Aiello AE
影响因子：
14.2
作者：
Abrahamsson, Thomas R.;Jakobsson, Hedvig E.;Jenmalm, Maria C.
通讯作者：
Jenmalm, Maria C.