Moderate to vigorous physical activity and sedentary time and cardiometabolic risk factors in children and adolescents.
Moderate to vigorous physical activity and sedentary time and cardiometabolic risk factors in children and adolescents.
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DOI：
10.1001/jama.2012.156
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发表时间：
2012-02-15
影响因子：
120.7
通讯作者：
Cooper, Ashley
中科院分区：
文献类型：
--
作者：
Ekelund, Ulf;Luan, Jian'an;Sherar, Lauren B.;Esliger, Dale W.;Griew, Pippa;Cooper, Ashley
关于健康儿童身体活动和久坐时间与心脏代谢风险因素之间联合关联的数据很少。
为了检验客观测量的中高强度身体活动时间和久坐时间与心脏代谢风险因素之间的独立及联合关联。
使用了1998年至2009年间收集的14项研究的汇总数据，这些数据来自国际儿童加速度计数据库，包含20871名儿童（4 - 18岁）。在重新分析原始数据文件后，使用加速度计测量中高强度身体活动时间和久坐时间。使用荟萃分析检验了中高强度身体活动时间和久坐时间与结果之间的独立关联。在联合分析中，参与者根据中高强度身体活动时间的三分位数和久坐时间的三分位数进行分层。
腰围、收缩压、空腹甘油三酯、高密度脂蛋白胆固醇和胰岛素。
儿童每天久坐时间为354±96分钟，中高强度身体活动时间为30±21分钟。中高强度身体活动时间与所有心脏代谢结果显著相关，且与性别、年龄、监测器佩戴时间、久坐时间和腰围（当腰围不是结果时）无关。久坐时间与任何结果均无关（在与中高强度身体活动时间无关的情况下）。在联合分析中，在不同的久坐时间三分位数中，中高强度身体活动水平越高，心脏代谢风险因素越好。久坐时间越低，中高强度身体活动水平高低之间的结果差异越大。中高强度身体活动时间最低和最高三分位数之间的腰围平均差异，在久坐时间长时为3.6厘米（95%置信区间，2.8 - 4.3），在久坐时间短时为5.6厘米（95%置信区间，4.8 - 6.4）。对于收缩压，久坐时间长时平均差异为0.7毫米汞柱（95%置信区间，-0.07 - 1.6），久坐时间短时为2.5毫米汞柱（95%置信区间，1.7 - 3.3）；对于高密度脂蛋白胆固醇，久坐时间长时为 -2.6毫克/分升（95%置信区间，-1.4 - -3.9），久坐时间短时为 -4.5毫克/分升（95%置信区间，-3.3 - -5.6）。胰岛素和甘油三酯的几何平均差异显示出类似的变化。中高强度身体活动时间处于最高三分位数的儿童每天在此强度水平上积累的时间>35分钟，而处于最低三分位数的儿童每天<18分钟。在前瞻性分析中（N = 6413，随访时间2.1年），中高强度身体活动和久坐时间在随访时均与腰围无关，而基线时腰围较高与随访时久坐时间较多有关。
儿童和青少年中高强度身体活动时间水平越高，无论久坐时间长短，心脏代谢风险因素越好。
Data on the combined associations between physical activity and sedentary time with cardio-metabolic risk factors in healthy children is sparse. To examine the independent and combined associations between objectively measured time in moderate and vigorous intensity physical activity and sedentary time with cardio-metabolic risk factors. Pooled data from 14 studies collected between 1998 and 2009 comprising 20,871 children (4-18 years) from the International Children’s Accelerometry Database was used. Time spent in moderate and vigorous physical activity and sedentary time was measured using accelerometry after reanalysing raw data files. The independent associations between time in moderate and vigorous physical activity and sedentary time with outcomes were examined using meta-analysis. In combined analyses, participants were stratified by tertiles of time spent in moderate and vigorous physical activity and tertiles of sedentary time. Waist circumference, systolic blood pressure, fasting triglycerides, HDL-Cholesterol and insulin. Children accumulated 354±96 min/d and 30±21 min/d sedentary and in MVPA, respectively. Time in moderate and vigorous physical activity was significantly associated with all cardio-metabolic outcomes independent of sex, age, monitor wear time, time spent sedentary and waist circumference (when waist circumference was not the outcome). Sedentary time was not associated with any outcome independent of time in moderate and vigorous physical activity. In the combined analyses, higher levels of moderate and vigorous physical activity were associated with better cardiometabolic risk factors across tertiles of sedentary time. The differences in outcomes between higher and lower moderate and vigorous physical activity were greater the lower the sedentary time. The mean differences in waist circumference between the bottom and top tertiles of moderate and vigorous physical activity varied between 3.6 cm (95% CI, 2.8-4.3) for high sedentary time to 5.6 (95% CI, 4.8-6.4) for low sedentary time. For systolic blood pressure, the mean differences were 0.7 mm Hg (95% CI, −0.07-1.6) for high sedentary time and 2.5 mm Hg (95% CI, 1.7-3.3) for low sedentary time, and for HDL-cholesterol, −2.6 mg/dL (95% CI, −1.4- −3.9) for high sedentary time and −4.5 mg/dL (95% CI, −3.3- −5.6) for low. Geometric mean differences for insulin and triglycerides showed similar variation. Children in the top tertile of MVPA accumulated >35 minutes/day in this intensity level compared with <18 minutes/day for those in the bottom tertile. In prospective analyses (N=6413, 2.1 yrs follow-up time), neither MVPA nor SED were associated with WC at follow-up, whereas a higher WC at baseline was associated with higher amounts of SED at follow-up. Higher levels of time spent in MVPA by children and adolescents were associated with better cardio-metabolic risk factors regardless of the amount of time spent sedentary.
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影响因子：
18.4
作者：
Eiberg, S;Hasselstrom, H;Andersen, LB
通讯作者：
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影响因子：
39.3
作者：
Healy, Genevieve N.;Matthews, Charles E.;Owen, Neville
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影响因子：
16.2
作者：
Ekelund, U;Brage, S;Wareham, NJ
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影响因子：
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作者：
Ekelund U;Brage S;Froberg K;Harro M;Anderssen SA;Sardinha LB;Riddoch C;Andersen LB
通讯作者：
Andersen LB
DOI：
10.1111/j.1600-0838.2011.01303.x
发表时间：
2011-12-01
影响因子：
4.1
作者：
Buchan, D. S.;Ollis, S.;Baker, J. S.
通讯作者：
Baker, J. S.