Modulatory role of estradiol in nicotinic antinociception in adult female rats.
Modulatory role of estradiol in nicotinic antinociception in adult female rats.
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雌二醇在成年雌性大鼠烟碱镇痛中的调节作用。
DOI：
10.1016/j.lfs.2009.04.021
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发表时间：
2009
期刊：
影响因子：
6.1
通讯作者：
Ting
中科院分区：
文献类型：
--
作者：
Yu Chen;Yu Cui;Jianwen Lin;Qiuling Xiang;Wei;Ting
目的最近的研究表明，男性和女性对尼古丁镇痛的反应存在差异，这种差异可能是由于性腺激素的调节作用所致。本研究的目的是研究雌性大鼠的烟碱抗伤害性反应以及雌二醇(E_2)对这种反应的影响。植入后第28天，鞘内注射高效烟碱型乙酰胆碱受体(NAChR)激动剂表巴替丁，通过甩尾实验评价脊髓水平的抗伤害性。此外，在脊髓切片上进行nAChRα4的免疫组织化学染色。我们发现雌性大鼠的伤害性潜伏期比雄性短，但对卵巢状况没有影响。然而，与正常女性相比，OVX显著增加了依巴替丁诱导的抗伤害作用，这种增加被E2治疗减弱。此外，与正常雌性大鼠相比，去卵巢大鼠背角nAChRα-4免疫阳性染色增加，且这种增加可被E2处理所减弱。本研究结果为雌鼠脊髓水平调控表巴替丁诱导的抗伤害效应提供了新证据。
AIMSDifferences in the response to nicotinic analgesia in males and females have been suggested by recent studies, and such differences are presumed to be due to the regulatory effects of gonadal hormones. The aim of this study was to investigate nicotinic antinociception and the effect of estradiol (E2) on this response in female rats.MAIN METHODSOvariectomized female rats were implanted with subcutaneous silastic tubes containing E2. On day 28 after implantation, epibatidine, a high-potency nicotinic acetylcholine receptor (nAChR) agonist, was administered intrathecally, and antinociception at the spinal level was assessed by the tail-flick test. In addition, immunohistochemical staining for nAChRα4 was performed in spinal cord sections.KEY FINDINGSWe found that female rats showed shorter nociceptive latencies than males, but there was no effect of ovarian status. However, OVX significantly increased epibatidine-induced antinociception compared to that in intact females, and this increase was attenuated by E2 treatment. In addition, OVX resulted in increased nAChRα4 immunostaining in the dorsal horn compared to that in intact females, and this increase was also attenuated by E2 treatment.SIGNIFICANCEResults of this study provide new evidence that E2 modulates epibatidine-induced antinociception at the spinal level in female rats.
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疼痛抑制、尼古丁和性别。
DOI：
10.1037//1064-1297.6.1.96
发表时间：
1998
期刊：
Experimental and clinical psychopharmacology.
影响因子：
--
作者：
Jamner,LD;Girdler,SS;Shapiro,D;Jarvik,ME
通讯作者：
Jarvik,ME
影响因子：
4.8
作者：
BRIDGES, RS
通讯作者：
BRIDGES, RS
胆碱能镇痛的性别差异II：两种异常性疼痛模型的不同机制。
影响因子：
8.8
作者：
Lavand'homme,PM;Eisenach,JC
通讯作者：
Eisenach,JC
影响因子：
4
作者：
Mannino, CA;South, SM;Quinones-Jenab, V
通讯作者：
Quinones-Jenab, V