Hypothesis: Bifunctional mitochondrial proteins have centrosomal functions.
Hypothesis: Bifunctional mitochondrial proteins have centrosomal functions.
复制标题
DOI：
10.1002/em.20508
复制
发表时间：
2009-10
影响因子：
2.8
通讯作者：
Golden, Andy
中科院分区：
文献类型：
--
作者：
Moore, Akilah;Golden, Andy
线粒体是参与许多不同过程的动态细胞器。最常见的是，线粒体与能量产生有关，但其他重要过程也发生在这个细胞器中，例如脂肪酸合成和氨基酸代谢。虽然线粒体编码不到40个基因，但其功能所需的所有其他1,000个基因都是核编码的。来自这些核编码基因的蛋白质产物随后被转运到线粒体，并在细胞器内的各种过程中被利用。那么，这些核编码的蛋白质是否有可能转移到细胞的其他区域，参与通常不属于线粒体的功能？越来越多的证据表明，线粒体蛋白不仅定位于细胞器外的位点，而且在这些其他位点也具有功能。我们认为，一个子集的核编码的线粒体蛋白是双功能的，并参与线粒体外的过程。从这个角度来看，我们将讨论已发表的数据，证明线粒体蛋白影响细胞周期的进展，改变染色体形态，定位到中心体，并影响细胞中的中心体数量。总的来说，线粒体是一个有趣的细胞器，参与各种重要功能。我们认为这些基本功能不仅仅是由于线粒体产生大量能量的能力。在整个讨论中，我们试图证明细胞不能没有线粒体，并从非能量的角度研究这个问题。Environ.摩尔诱变剂，2009. 2009年发布Wiley利斯，Inc.
Mitochondria are dynamic organelles that are involved in a number of diverse processes. Most often the mitochondrion is associated with energy generation, but other important processes occur in this organelle such as fatty acid synthesis and amino acid metabolism. Although mitochondria encode less than 40 genes, all of the other ∼1,000 genes required for their function are nuclear encoded. The protein products from these nuclear encoded genes are subsequently translocated to the mitochondria and utilized in the variety of processes within the organelle. Is it possible then that any of these nuclear encoded proteins could be translocated to other areas of the cell to participate in functions not normally attributed to the mitochondria? There is growing evidence that mitochondrial proteins not only localize to sites outside of the organelle, but also have functionality at these other locales. We suggest that a subset of nuclear encoded mitochondrial proteins are bifunctional and are involved in processes outside of the mitochondria. In this perspective, we will discuss published data demonstrating mitochondrial proteins that influence progression of the cell cycle, alter chromosome morphology, localize to centrosomes, and affect centrosome number in the cell. Overall, the mitochondrion is an interesting organelle that participates in a variety of vital functions. We suggest that these essential functions are not solely due to the ability of the mitochondria to produce high amounts of energy. Throughout this discussion we attempt to demonstrate that a cell cannot live without mitochondria and study this issue from a nonenergetic perspective. Environ. Mol. Mutagen., 2009. Published 2009 Wiley‐Liss, Inc.
登录
查看更多内容
DOI：
10.1196/annals.1354.022
发表时间：
2006-01-01
期刊：
UNDERSTANDING AND MODULATING AGING
影响因子：
--
作者：
Singh, Keshav K.
通讯作者：
Singh, Keshav K.
影响因子：
64.8
作者：
Andersen, JS;Wilkinson, CJ;Mann, M
通讯作者：
Mann, M
影响因子：
4.4
作者：
Jeffery, CJ
通讯作者：
Jeffery, CJ
DOI：
10.1083/jcb.200202027
发表时间：
2002-05-27
期刊：
The Journal of cell biology
影响因子：
--
作者：
Helfand BT;Mikami A;Vallee RB;Goldman RD
通讯作者：
Goldman RD
DOI：
10.1083/jcb.147.1.135
发表时间：
1999-10-04
期刊：
The Journal of cell biology
影响因子：
--
作者：
Gönczy P;Pichler S;Kirkham M;Hyman AA
通讯作者：
Hyman AA