Genetic influences on heart rate variability at rest and during stress.
Genetic influences on heart rate variability at rest and during stress.
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DOI：
10.1111/j.1469-8986.2009.00793.x
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发表时间：
2009-05
期刊：
影响因子：
3.7
通讯作者：
Snieder H
中科院分区：
文献类型：
--
作者：
Wang X;Ding X;Su S;Li Z;Riese H;Thayer JF;Treiber F;Snieder H
我们测试了压力下心率变异性（HRV）的遗传性是否与休息时不同，以及它对种族或性别的依赖性。以连续差异均方根（RMSSD）和高频（HF）功率为指标测量了427名欧洲双胞胎和308名非洲裔美国双胞胎在静息和3种应激条件下的HRV。在任何测量中都没有发现种族或性别差异。胁迫作用下RMSSD和HF的遗传力分别从0.48增加到0.58和0.50增加到0.58。压力下RMSSD和HF的遗传力分别高达81%和60%可归因于影响休息水平的基因。胁迫下基因表达的遗传力RMSSD为0.11，HF为0.23。研究结果表明，与种族和性别无关，休息和压力下的HRV调节在很大程度上受到相同基因的影响，压力特异性遗传效应的贡献虽小，但却很重要。
We tested whether the heritability of heart rate variability (HRV) under stress is different from rest and its dependency on ethnicity or gender. HRV indexed by root mean square of successive differences (RMSSD) and high-frequency (HF) power was measured at rest and during 3 stressors in 427 European and 308 African American twins. No ethnic or gender differences were found for any measures. There was a nonsignificant increase in heritability of RMSSD (from 0.48 to 0.58) and HF (from 0.50 to 0.58) under stress. Up to 81% and 60% of the heritabilities of RMSSD and HF under stress could be attributed to genes influencing rest levels. The heritabilities due to genes expressed under stress were 0.11 for RMSSD and 0.23 for HF. The findings suggest that, independent of ethnicity and gender, HRV regulation at rest and under stress is largely influenced by the same genes with a small but significant contribution of stress-specific genetic effects.
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影响因子：
158.5
作者：
BOUCHARD, C;TREMBLAY, A;FOURNIER, G
通讯作者：
FOURNIER, G
影响因子：
5.1
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通讯作者：
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2.7
作者：
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作者：
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通讯作者：
de Geus, EJC
影响因子：
3.3
作者：
Neumann, SA;Lawrence, EC;Manuck, SB
通讯作者：
Manuck, SB