Mitochondrial epigenetics in bone remodeling during hyperhomocysteinemia.
Mitochondrial epigenetics in bone remodeling during hyperhomocysteinemia.
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DOI：
10.1007/s11010-014-2114-3
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发表时间：
2014-10
影响因子：
4.3
通讯作者：
Tyagi N
中科院分区：
文献类型：
--
作者：
Kalani A;Kamat PK;Voor MJ;Tyagi SC;Tyagi N
同型半胱氨酸（Hcy）水平升高，称为高同型半胱氨酸血症（HHcy），是多种疾病的独立危险因素。临床研究报告说，出生时患有严重HHcy的人会出现骨骼畸形，骨骼较弱。研究还报告说，线粒体动力学的改变和表观遗传学的改变有助于骨骼脆弱和骨骼疾病。虽然Hcy诱导的线粒体功能障碍已被证明会影响骨代谢，但线粒体表观遗传学（mito-epigenetics）的作用尚未在骨骼中研究。线粒体中的表观遗传学是令人感兴趣的，因为线粒体基因组大小很小（16 kb），具有较少的CpG，并且没有组蛋白和内含子。最近，表观遗传学的研究沿着线粒体中组蛋白样蛋白的发现，为线粒体表观遗传学的新研究提供了令人兴奋的领域。骨、线粒体、同型半胱氨酸和表观遗传学之间存在相互因果关系，但不幸的是，缺乏描述所有这些共同参与骨疾病进展的研究。本文综述了Hcy-骨-线粒体-表观遗传学的相互关系和机制沿着并简要讨论了通过线粒体表观遗传学改变介导的评估Hcy诱导骨异常的技术。
Elevated levels of homocysteine (Hcy), known as hyperhomocysteinemia (HHcy), is an independent risk factor of various diseases. Clinical studies report that people born with severe HHcy develop skeletal malformations with weaker bone. Studies also report that altered mitochondrial dynamics and altered epigenetics contribute to weaker bones and bone diseases. Although Hcy-induced mitochondrial dysfunction has been shown to affect bone metabolism, the role of mitochondrial epigenetics (mito-epigenetics) has not been studied in bones. The epigenetics in mitochondria is interesting as the mitochondrial genome size is small (16 kb) with fewer CpG, and without histones and introns. Recently, fascinating works on epigenetics along with the discovery of histone-like proteins in mitochondria are giving exciting areas for novel studies on mitochondria epigenetics. There are mutual cause and effect relationships between bone, mitochondria, Hcy, and epigenetics but unfortunately, studies are lacking which describe the involvement of all these together in bone disease progression. This review describes the reciprocal relationships and mechanisms of Hcy-bone-mitochondria-epigenetics along with a short discussion of techniques which could be employed to assess Hcy-induced anomaly in bone, mediated through alterations in mitochondrial epigenetics.
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影响因子：
8.2
作者：
Fu, Li-hong;Ma, Chun-ling;Zhang, Jing-ge
通讯作者：
Zhang, Jing-ge
影响因子：
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作者：
Choi, Yon-Sik;Jeong, Jae Hoon;Pak, Youngmi Kim
通讯作者：
Pak, Youngmi Kim
影响因子：
6.2
作者：
Gerdhem, Paul;Ivaska, Kaisa K.;Akesson, Kristina
通讯作者：
Akesson, Kristina
影响因子：
--
作者：
Gjesdal, CG;Vollset, SE;Tell, GS
通讯作者：
Tell, GS
影响因子：
6.2
作者：
Gjesdal, Clara Gram;Vollset, Stein Emil;Tell, Grethe S.
通讯作者：
Tell, Grethe S.