Influence of polysaccharides on the dynamic self-assembly of medium-chain fatty acid vesicles and hydrolysis of decanoic acid anhydrides
Influence of polysaccharides on the dynamic self-assembly of medium-chain fatty acid vesicles and hydrolysis of decanoic acid anhydrides
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多糖对中链脂肪酸囊泡动态自组装及癸酸酐水解的影响
DOI：
10.1016/j.colsurfa.2018.07.055
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发表时间：
2018-10
期刊：
影响因子：
--
通讯作者：
Zhong Xiu Chen
中科院分区：
文献类型：
--
作者：
Ming Qiang Jia;Qi Zheng Liu;Li Juan Zhu;Yan Zhang;Zhong Xiu Chen
脂肪酸酐的水解包括脂肪酸囊泡的形成和自催化水解。以前的研究集中在生物聚合物对囊泡形成或自催化反应的影响，然而，多糖对脂肪酸囊泡的自组装和脂肪酸酐的水解共存的系统的影响仍然未知。以硫酸软骨素钠（CSA）、海藻酸钠（SA）和2-羟乙基纤维素（2-HEC）3种多糖为研究对象，研究了拥挤培养基对癸酸囊泡形成和癸酸酐自催化水解的影响。结果表明，CSA和SA使癸酸酐的水解速率增加，而2-HEC使癸酸酐的水解速率降低。进一步的研究表明，在囊泡形成的早期阶段，CSA中囊泡的大小减小，而2-HEC中囊泡的大小增加。在CSA-囊泡系统中，弹性行为占主导地位，而2-HEC-和SA-囊泡显示出更粘性的行为。此外，CSA或SA中显著增加的膜流动性支持癸酸囊泡的自组装和自催化水解，这在2-HEC的情况下是相反的。这项研究为在拥挤条件下脂肪酸囊泡的自组装和囊泡催化与多糖的反应提供了新的见解。
Hydrolysis of fatty acid anhydrides involves fatty acid vesicle formation and autocatalytic hydrolysis. Previous studies focused on the effect of biopolymers on vesicle formation or on autocatalytic reactions, however, the influence of polysaccharides on a system where the self-assembly of fatty acid vesicles and the hydrolysis of fatty acid anhydrides coexist remains unknown. In this paper, three polysaccharides, sodium chondroitin sulfate (CSA), sodium alginate (SA) and 2-hydroxyethyl cellulose (2-HEC) were selected to investigate the effect of crowded media on the decanoic acid vesicle formation and the autocatalytic hydrolysis of decanoic anhydride. The results showed that the rate of hydrolysis of decanoic anhydride increased in CSA or SA but decreased in 2-HEC. Further investigation revealed that the size of vesicles in CSA decreased in the early stage of vesicle formation but increased in 2-HEC. In the CSA-vesicle system, elastic behavior dominates, while 2-HEC- and SA-vesicles show more viscous behavior. In addition, the significantly increased membrane fluidity in CSA or in SA supports self-assembly of decanoic acid vesicles and autocatalytic hydrolysis, which is the opposite in the case of 2-HEC. This research provides new insights into the self-assembly of fatty acid vesicles and vesicle-catalyzed reactions with polysaccharides in crowded conditions.
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DOI：
10.1016/0167-4838(89)90273-2
发表时间：
1989-10-05
期刊：
BIOCHIMICA ET BIOPHYSICA ACTA
影响因子：
--
作者：
DEMCHENKO, AP;RUSYN, OI;SABUROVA, EA
通讯作者：
SABUROVA, EA
影响因子：
3
作者：
RALSTON, GB
通讯作者：
RALSTON, GB
影响因子：
3.3
作者：
Cao, Cao;Wang, Qing-Biao;Deng, Shao-Ping
通讯作者：
Deng, Shao-Ping
影响因子：
3.9
作者：
C. Vogl;M. Miksis;S. H. Davis;D. Salac
通讯作者：
C. Vogl;M. Miksis;S. H. Davis;D. Salac
影响因子：
5.8
作者：
H. W. Tan;M. Misran
通讯作者：
H. W. Tan;M. Misran