Single-nucleotide polymorphisms of allergy-related genes and risk of adult glioma.
Single-nucleotide polymorphisms of allergy-related genes and risk of adult glioma.
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DOI：
10.1007/s11060-013-1122-6
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发表时间：
2013-06
影响因子：
3.9
通讯作者：
Michaud, Dominique S.
中科院分区：
文献类型：
--
作者：
Backes, Danielle M.;Siddiq, Afshan;Cox, David G.;Calboli, Federico C. F.;Gaziano, J. Michael;Ma, Jing;Stampfer, Meir;Hunter, David J.;Camargo, Carlos A.;Michaud, Dominique S.
先前的研究已经表明过敏和胶质瘤风险之间的负相关性;然而，过敏相关基因的单核苷酸多态性（SNP）和胶质瘤风险之间的关联结果不一致，并且仅限于少数SNP。本研究的目的是研究21个过敏相关基因的166个SNP与神经胶质瘤风险之间的关联，该研究采用巢式病例对照研究，研究对象来自美国三项大型前瞻性队列研究。在病例诊断之前，在562名白人参与者（143例病例和419例匹配对照）中于1982年至1994年期间采集血液。使用定制的Illumina测定芯片进行基因分型。Logistic回归分析，控制年龄和研究队列，用于确定每个SNP和胶质瘤风险之间的关联。在编码高亲和力免疫球蛋白E受体α链的FCER 1A基因的rs 2494262和rs 2427824与胶质瘤风险之间发现了统计学显著相关性（标称趋势p值分别为0.01和0.03）。还发现IL 10、ADAM 33、NOS 1和IL 4 R中的SNP与神经胶质瘤风险之间存在显着相关性;然而，这些并未在多重比较中得到纠正，需要谨慎解释。我们对FCER 1A SNPs的研究结果为过敏和神经胶质瘤风险之间的联系提供了进一步的支持。
Previous studies have shown an inverse association between allergies and glioma risk; however, results for associations between single nucleotide polymorphisms (SNPs) of allergy-related genes and glioma risk have been inconsistent and restricted to a small number of SNPs. The objective of this study was to examine the association between 166 SNPs of 21 allergy-related genes and glioma risk in a nested case-control study of participants from three large US prospective cohort studies. Blood collection took place between 1982 and 1994 among the 562 included Caucasian participants (143 cases and 419 matched controls) prior to case diagnosis. Custom Illumina assay chips were used for genotyping. Logistic regression analyses, controlling for age and study cohort, were used to determine associations between each SNP and glioma risk. Statistically significant associations were found between rs2494262 and rs2427824 of the FCER1A gene, which encodes the alpha chain of the high affinity immunoglobulin E receptor, and glioma risk (nominal trend p-values 0.01 and 0.03, respectively). Significant associations were also found between SNPs in IL10, ADAM33, NOS1 and IL4R and glioma risk; however, these were not corrected for multiple comparisons and need to be interpreted with caution. Our findings with FCER1A SNPs provide further support for the link between allergies and risk of glioma.
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全基因组扫描在总血清IgE水平上鉴定出FCER1A是新的敏感性基因座。
影响因子：
4.5
作者：
Weidinger, Stephan;Gieger, Christian;Rodriguez, Elke;Baurecht, Hansjoerg;Mempel, Martin;Klopp, Norman;Gohlke, Henning;Wagenpfeil, Stefan;Ollert, Markus;Ring, Johannes;Behrendt, Heidrun;Heinrich, Joachim;Novak, Natalija;Bieber, Thomas;Kraemer, Ursula;Berdel, Dietrich;von Berg, Andrea;Bauer, Carl Peter;Herbarth, Olf;Koletzko, Sibylle;Prokisch, Holger;Mehta, Divya;Meitinger, Thomas;Depner, Martin;von Mutius, Erika;Liang, Liming;Moffatt, Miriam;Cookson, William;Kabesch, Michael;Wichmann, H. -Erich;Illig, Thomas
通讯作者：
Illig, Thomas
影响因子：
10.3
作者：
Linos, Eleni;Raine, Tim;Michaud, Dominique
通讯作者：
Michaud, Dominique
影响因子：
3.8
作者：
Schwartzbaum, Judith A.;Ahlbom, Anders;Feychting, Maria
通讯作者：
Feychting, Maria
影响因子：
168.9
作者：
RIMM, EB;GIOVANNUCCI, EL;STAMPFER, MJ
通讯作者：
STAMPFER, MJ
影响因子：
5.3
作者：
Rajaraman, Preetha;Melin, Beatrice S.;Wang, Zhaoming;McKean-Cowdin, Roberta;Michaud, Dominique S.;Wang, Sophia S.;Bondy, Melissa;Houlston, Richard;Jenkins, Robert B.;Wrensch, Margaret;Yeager, Meredith;Ahlbom, Anders;Albanes, Demetrius;Andersson, Ulrika;Freeman, Laura E. Beane;Buring, Julie E.;Butler, Mary Ann;Braganza, Melissa;Carreon, Tania;Feychting, Maria;Fleming, Sarah J.;Gapstur, Susan M.;Gaziano, J. Michael;Giles, Graham G.;Hallmans, Goran;Henriksson, Roger;Hoffman-Bolton, Judith;Inskip, Peter D.;Johansen, Christoffer;Kitahara, Cari M.;Lathrop, Mark;Liu, Chenwei;Le Marchand, Loic;Linet, Martha S.;Lonn, Stefan;Peters, Ulrike;Purdue, Mark P.;Rothman, Nathaniel;Ruder, Avima M.;Sanson, Marc;Sesso, Howard D.;Severi, Gianluca;Shu, Xiao-Ou;Simon, Matthias;Stampfer, Meir;Stevens, Victoria L.;Visvanathan, Kala;White, Emily;Wolk, Alicja;Zeleniuch-Jacquotte, Anne;Zheng, Wei;Decker, Paul;Enciso-Mora, Victor;Fridley, Brooke;Gao, Yu-Tang;Kosel, Matthew;Lachance, Daniel H.;Lau, Ching;Rice, Terri;Swerdlow, Anthony;Wiemels, Joseph L.;Wiencke, John K.;Shete, Sanjay;Xiang, Yong-Bing;Xiao, Yuanyuan;Hoover, Robert N.;Fraumeni, Joseph F., Jr.;Chatterjee, Nilanjan;Hartge, Patricia;Chanock, Stephen J.
通讯作者：
Chanock, Stephen J.