The contribution of multiple long-term conditions to widening inequalities in disability-free life expectancy over two decades: Longitudinal analysis of two cohorts using the Cognitive Function and Ageing Studies.

The contribution of multiple long-term conditions to widening inequalities in disability-free life expectancy over two decades: Longitudinal analysis of two cohorts using the Cognitive Function and Ageing Studies.
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多个长期条件对在二十年中无残障预期寿命的不平等的贡献:使用认知功能和衰老研究对两个人群进行纵向分析。

DOI:
10.1016/j.eclinm.2021.101041
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发表时间:
2021-09
期刊:
影响因子:
15.1
通讯作者:
Jagger C
Jagger C
中科院分区:
医学1区
文献类型:
--
作者:
Bennett HQ;Kingston A;Lourida I;Robinson L;Corner L;Brayne CE;Matthews FE;Jagger C

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社会经济贫困导致的无残疾预期寿命(DFLE)不平等正在扩大,同时多种长期疾病(MLTC)的患病率也在上升。我们使用纵向数据来评估MLTC是否有助于扩大DFLE不平等的社会经济剥夺。认知功能和老龄化研究(CFAS I和II)是在英格兰的三个地区进行的以≥65岁人群为基础的大型研究。基线发生在1991年(CFAS I,n=7635)和2011年(CFAS II,n=7762),随访2年。我们将残疾定义为日常生活活动的困难,MLTC定义为九种健康状况中至少有两种,以及按地区水平剥夺三分位数的社会经济剥夺。DFLE和残疾状态和死亡之间的过渡估计从多状态模型。对于MLTC患者,到2011年,65岁时最富裕和最不富裕之间的DFLE不平等扩大到约2.5年(男性:2.4年,95%置信区间(95%CI)0.4-4.4;女性:2.6年,95%CI 0.7-4.5)。最富裕女性的意外残疾减少(相对风险比(RRR):0.6,95%CI 0.4-0.9),最不富裕男性的残疾死亡率减少(RRR:0.6,95%CI 0.5-0.8)。只有最不富裕的男性(1991年:58.8%,2011年:66.9%)和女性(1991年:60.9%,2011年:69.1%)的多层肺结核患病率有所上升。然而,在没有MLTC的人群中,DFLE不平等同样大(男性:2.4年,95%CI 0.3-4.5;女性:3.1年,95%CI 0.8-5.4)。:扩大的DFLE不平等不仅仅是由于MLTC。降低MLTC的残疾发生率是可能的,但只有在最富裕的国家才能实现。
: Disability-free life expectancy (DFLE) inequalities by socioeconomic deprivation are widening, alongside rising prevalence of multiple long-term conditions (MLTCs). We use longitudinal data to assess whether MLTCs contribute to the widening DFLE inequalities by socioeconomic deprivation. : The Cognitive Function and Ageing Studies (CFAS I and II) are large population-based studies of those ≥65 years, conducted in three areas in England. Baseline occurred in 1991 (CFAS I, n=7635) and 2011 (CFAS II, n=7762) with two-year follow-up. We defined disability as difficulty in activities of daily living, MLTCs as the presence of at least two of nine health conditions, and socioeconomic deprivation by area-level deprivation tertiles. DFLE and transitions between disability states and death were estimated from multistate models. : For people with MLTCs, inequalities in DFLE at age 65 between the most and least affluent widened to around 2.5 years (men:2.4 years, 95% confidence interval (95%CI) 0.4–4.4; women:2.6 years, 95%CI 0.7–4.5) by 2011. Incident disability reduced for the most affluent women (Relative Risk Ratio (RRR):0.6, 95%CI 0.4–0.9), and mortality with disability reduced for least affluent men (RRR:0.6, 95%CI 0.5–0.8). MLTCs prevalence increased only for least affluent men (1991: 58.8%, 2011: 66.9%) and women (1991: 60.9%, 2011: 69.1%). However, DFLE inequalities were as large in people without MLTCs (men:2.4 years, 95%CI 0.3–4.5; women:3.1 years, 95% CI 0.8–5.4). : Widening DFLE inequalities were not solely due to MLTCs. Reduced disability incidence with MLTCs is possible but was only achieved in the most affluent.
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