Association of Circulating IgE and CML Levels with In-Stent Restenosis in Type 2 Diabetic Patients with Stable Coronary Artery Disease.
Association of Circulating IgE and CML Levels with In-Stent Restenosis in Type 2 Diabetic Patients with Stable Coronary Artery Disease.
复制标题
患有稳定型冠状动脉疾病的 2 型糖尿病患者循环 IgE 和 CML 水平与支架内再狭窄的关系
DOI：
10.3390/jcdd9050157
复制
发表时间：
2022-05-13
影响因子：
2.4
通讯作者：
Wu, Liqun
中科院分区：
文献类型：
--
作者：
Liu, Jingmeng;Chen, Qiujing;Lu, Lin;Jin, Qi;Bao, Yangyang;Ling, Tianyou;Lin, Changjian;Ding, Fenghua;Wang, Xiaoqun;Shen, Weifeng;Shen, Ying;Dai, Yang;Wu, Liqun
关键词：
背景资料：本研究旨在探讨血清免疫球蛋白（IG）E和Nε-羧甲基赖氨酸（CML）水平是否与稳定性冠心病合并2型糖尿病（T2 DM）患者支架内再狭窄（ISR）相关。研究方法：在196例ISR患者和220例非ISR稳定型心绞痛和T2 DM患者中测量血清IgE和CML水平，这些患者在经皮冠状动脉介入治疗（PCI）后12个月接受血管造影随访，其中第三代药物洗脱支架（DES）植入治疗原发病变。采用多因素Logistic回归分析评估IgE或CML与ISR的相关性。结果如下：ISR患者的IgE和CML水平均高于非ISR患者（IgE：187.10（63.75-489.65）vs. 80.25（30.65-202.50），p < 0.001; CML：203.26（164.50-266.84）vs. 174.26（130.85-215.56），p < 0.001）。ISR率随IgE和CML水平三分位数的增加而逐步增加（所有趋势p < 0.001），IgE与CML显著相关。调整潜在混杂因素后，IgE和CML水平仍与ISR独立相关。此外，IgE和CML水平提高了传统危险因素对ISR的预测能力，并且IgE和CML在ISR方面存在交互作用（交互作用p < 0.01）。结论：在2型糖尿病合并稳定性冠状动脉疾病患者中，循环IgE和CML水平升高可增加DES PCI术后ISR的风险。
Background: We investigated whether serum levels of immunoglobin (Ig) E and Nε-carboxymethyl-lysine (CML) are related to in-stent restenosis (ISR) in patients with stable coronary artery disease and type 2 diabetes mellitus (T2DM). Methods: Serum levels of IgE and CML were measured in 196 ISR patients and 220 non-ISR patients with stable angina and T2DM who received angiographic follow-up 12 months after percutaneous coronary intervention (PCI) with third-generation drug-eluting stent (DES) implantation for de novo lesions. Multivariate logistic regression analysis was performed to assess the association between IgE or CML and ISR. Results: Both IgE and CML levels were higher in patients with ISR compared with non-ISR patients (IgE: 187.10 (63.75–489.65) vs. 80.25 (30.65–202.50), p < 0.001; CML: 203.26 (164.50–266.84) vs. 174.26 (130.85–215.56), p < 0.001). The rate of ISR increased stepwise with increasing tertiles of IgE and CML levels (p for all trends < 0.001), and IgE correlated significantly with CML. After adjusting for potential confounders, IgE and CML levels remained independently associated with ISR. Moreover, IgE and CML levels improved the predictive capability of traditional risk factors for ISR, and there existed an interaction between IgE and CML in relation to ISR (p for interaction < 0.01). Conclusion: Elevated circulating IgE and CML levels confer an increased risk for ISR after DES-based PCI in type 2 diabetic patients with stable coronary artery disease.
登录
查看更多内容
影响因子：
24
作者：
Carter, Paul;Lagan, Jakub;Miller, Christopher A.
通讯作者：
Miller, Christopher A.
影响因子：
24
作者：
Alfonso, Fernando;Byrne, Robert A.;Kastrati, Adnan
通讯作者：
Kastrati, Adnan
血清 IgE 水平与冠状动脉疾病严重程度相关
影响因子：
5.3
作者：
Guo, Xiaoxiao;Yuan, Su;Shen, Zhujun
通讯作者：
Shen, Zhujun
影响因子：
2.8
作者：
Han, Kaiyu;Suzukawa, Maho;Ohta, Ken
通讯作者：
Ohta, Ken
影响因子：
4.6
作者：
Kim MK;Jeong JS;Han K;Baek KH;Song KH;Kwon HS
通讯作者：
Kwon HS