House dust mite and Cockroach specific Immunoglobulin E sensitization is associated with diabetes mellitus in the adult Korean population.
House dust mite and Cockroach specific Immunoglobulin E sensitization is associated with diabetes mellitus in the adult Korean population.
复制标题
DOI：
10.1038/s41598-018-20573-0
复制
发表时间：
2018-02-08
影响因子：
4.6
通讯作者：
Kwon HS
中科院分区：
文献类型：
--
作者：
Kim MK;Jeong JS;Han K;Baek KH;Song KH;Kwon HS
已知免疫球蛋白 E (IgE) 可以激活肥大细胞。先前的研究表明，肥大细胞会导致饮食引起的肥胖和糖尿病 (DM)。我们的目的是确定 IgE 致敏的成年人是否有患糖尿病的风险。我们对从不同地区各个年龄和性别组中随机抽取的 1,528 名成年人进行了针对屋尘螨、蟑螂和狗的血清总 IgE 和过敏原特异性 IgE 水平的测定。总 IgE 水平和三种过敏原特异性 IgE 水平与空腹血糖水平和胰岛素抵抗呈正相关。与总 IgE 水平升高 (>100 kU/L) 的受试者相比，总 IgE 水平升高的受试者在调整各种协变量后，DM 的比值比 (OR) 为 1.72（95% 置信区间 [95% CI]，1.17–2.54）。进一步控制既往过敏性疾病并没有减弱总 IgE 水平与 DM 之间的关联。对屋尘螨（OR 1.63，95% CI，1.03-2.59）和蟑螂（OR 2.27，95% CI，1.40-3.66）敏感的受试者患糖尿病的风险也增加。我们发现，在一般韩国人群中，IgE 致敏与 DM 之间存在很强的正相关性，这表明 IgE 可能是韩国人代谢性疾病的重要独立危险因素。
Immunoglobulin E (IgE) is known to activate mast cells. Prior studies have shown that mast cells contribute to diet-induced obesity and diabetes mellitus (DM). We aimed to determine whether adults with IgE sensitization were at risk of DM. We performed assays regarding serum total IgE and allergen-specific IgE levels against the house dust mite, the cockroach, and the dog on 1,528 adults randomly sampled from every age and gender group in various districts. The total and three allergen-specific IgE levels were positively correlated with fasting glucose level and insulin resistance. Subjects with increased levels of total IgE (>100 kU/L), compared to those without, had an odds ratio (OR) of 1.72 (95% confidence interval [95% CI], 1.17–2.54) for DM after adjusting for various covariates. Further controlling for previous allergic disease did not attenuate the association between total IgE level and DM. Subjects sensitized to the house dust mite (OR 1.63, 95% CI, 1.03–2.59) and the cockroach (OR 2.27, 95% CI, 1.40–3.66) were also at increased risk of DM. We found a strong positive association between IgE sensitization and DM in a general Korean population, suggesting that IgE may be an important independent risk factor for metabolic diseases in Koreans.
登录
查看更多内容
影响因子：
3.7
作者：
Wang Z;Zhang H;Shen XH;Jin KL;Ye GF;Qian L;Li B;Zhang YH;Shi GP
通讯作者：
Shi GP
影响因子：
7.3
作者：
Shi MA;Shi GP
通讯作者：
Shi GP
影响因子：
5.9
作者：
Song, Sun Ok;Song, Young Duk;Lim, Dong-Ha
通讯作者：
Lim, Dong-Ha
影响因子：
15.9
作者：
Sun, Jiusong;Sukhova, Galina K.;Shil, Guo-Ping
通讯作者：
Shil, Guo-Ping
DOI：
10.1084/jem.20111155
发表时间：
2011-12-19
期刊：
The Journal of experimental medicine
影响因子：
--
作者：
Wesemann DR;Magee JM;Boboila C;Calado DP;Gallagher MP;Portuguese AJ;Manis JP;Zhou X;Recher M;Rajewsky K;Notarangelo LD;Alt FW
通讯作者：
Alt FW