Risk-Benefit Modeling to Guide Health Research in Collaboration with Great Lakes Fish Consuming Native American Communities.
Risk-Benefit Modeling to Guide Health Research in Collaboration with Great Lakes Fish Consuming Native American Communities.
复制标题
DOI：
10.1016/j.jglr.2020.08.003
复制
发表时间：
2020-12
影响因子：
2.2
通讯作者：
Ripley M
中科院分区：
文献类型：
--
作者：
Dellinger MJ;Anguzu R;Pingatore N;Ripley M
有充分的文件证明，食用鱼类既会带来健康风险，也会带来好处。此外，捕捞和消费鱼类是五大湖美洲原住民文化的重要组成部分。将风险和收益与潜在消费情景进行比较的量化模型可以帮助指导未来的健康研究以及针对潜在敏感人群的消费建议。这篇文章介绍了基于东部上半岛和密歇根州北部Anishinaabe部落成员构建的自我报告的膳食计划的鱼类消费情景。两个风险-效益模型被应用于这些情景，以估计二恶英样多氯联苯(DL-PCbs)、甲基汞(MeHg)和omega-3多不饱和脂肪酸(n3-PUFA)的潜在神经发育和心血管风险(增加或降低风险)。除了最大暴露估计(即第25-75百分位数的甲基汞、DL-多氯联苯和n3-多不饱和脂肪酸摄入量)以外的所有情况都预示着心血管风险的降低和神经发育结果的改善。最大的预期收益(经风险调整)出现在摄入甲基汞、DL-多氯联苯和n3-PUFA情景的第75个百分位数：视觉回忆记忆(VRM)和4.41智商(IQ)收益，心血管疾病风险降低28%。然而，基于自我报告的最大摄入量的情景预测了健康损害。这些结果表明，与美洲原住民社区合作构建的大多数鱼类消费情景可能会带来健康益处，尽管存在污染物。然而，高端消费估计值得谨慎，也需要精心设计的建议。潜在的惠益进一步突出了减少五大湖渔业污染负担的价值。讨论了正在进行的污染监测和健康研究的未来优先事项。
It is well documented that fish consumption imparts both health risks and benefits. Furthermore, fish harvest and consumption are an essential part of Great Lakes Native American cultures. Quantitative models that compare risk and benefits to potential consumption scenarios can help guide future health research as well as consumption advice for potentially sensitive populations. This article presents fish consumption scenarios based on self-reported meal plans constructed by tribal members in eastern upper peninsula and northern lower Michigan Anishinaabe. Two risk-benefit models were applied to these scenarios to estimate the potential neurodevelopmental and cardiovascular risks (either increased or reduced risk) from dioxin-like polychlorinated biphenyls (DL-PCBs), methylmercury (MeHg), and omega-3 polyunsaturated fatty acids (n3-PUFA). All scenarios except maximum exposure estimates (i.e. 25th–75th percentile MeHg, DL-PCB, and n3-PUFA intakes) predicted reduced cardiovascular risk and improved neurodevelopmental outcomes. The greatest predicted benefits (adjusted for risks) occurred at the 75th percentile intake of MeHg, DL-PCB, and n3-PUFA scenarios: 5.0 visual recall memory (VRM) and 4.41 Intelligence Quotient (IQ) benefits, and 28% reduced risk of cardio-vascular disease. Scenarios based on maximum self-reported intake, however, predicted health detriments. These results suggest that most fish consumption scenarios as constructed in collaboration with Native American communities could impart health benefits despite the presence of contaminants. However, high-end consumption estimates warrant caution as well as the need for well-crafted advice. Potential benefits further underscore the value of reducing contamination burdens in Great Lakes fisheries. Future priorities of ongoing contamination monitoring and health research are discussed.
登录
查看更多内容
影响因子：
4.3
作者：
Ginsberg, G. L.;Toal, B. F.;McCann, P. J.
通讯作者：
McCann, P. J.
影响因子：
8.3
作者：
Dellinger, JA
通讯作者：
Dellinger, JA
影响因子：
10.4
作者：
Finn, Symma;Herne, Mose;Castille, Dorothy
通讯作者：
Castille, Dorothy
影响因子：
1.3
作者：
Johnson, Jennifer S.;Nobmann, Elizabeth D.;Lanier, Anne P.
通讯作者：
Lanier, Anne P.
影响因子：
4.1
作者：
Bhavsar, Satyendra P.;Hayton, Alan;Jackson, Donald A.
通讯作者：
Jackson, Donald A.