Adenovirus and herpesvirus diversity in free-ranging great apes in the Sangha region of the Republic Of Congo.
Adenovirus and herpesvirus diversity in free-ranging great apes in the Sangha region of the Republic Of Congo.
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DOI：
10.1371/journal.pone.0118543
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发表时间：
2015
期刊：
影响因子：
3.7
通讯作者：
Lipkin WI
中科院分区：
文献类型：
--
作者：
Seimon TA;Olson SH;Lee KJ;Rosen G;Ondzie A;Cameron K;Reed P;Anthony SJ;Joly DO;Karesh WB;McAloose D;Lipkin WI
传染病已经导致自由放养的大猩猩和黑猩猩的死亡。因此，了解病原体多样性和疾病生态对于保护这些濒危动物至关重要。为了确定刚果共和国自由放养的非习惯性大猩猩和黑猩猩的病毒多样性，对奥扎拉-科库瓦国家公园附近采集的大猩猩粪便样本进行了基因测试。分析样本以确定类人猿物种，识别种群中的个体，并测试疱疹病毒、腺病毒、痘病毒、博卡病毒、黄病毒、副粘病毒、冠状病毒、丝状病毒和猿类免疫缺陷病毒(SIV)的存在。我们鉴定了19种DNA病毒，分别代表疱疹病毒科和腺病毒科两个病毒科，其中三种疱疹病毒以前没有被描述过。在大猩猩和黑猩猩中都存在多种疱疹病毒和/或腺病毒的共同检测。巨细胞病毒(CMV)和淋巴病毒(LCV)最初是在彼此和腺病毒相互关联的背景下被发现的。利用疱疹病毒和腺病毒的病毒发现曲线，大猩猩和黑猩猩样本种群中的总病毒丰度估计至少为23种病毒，对应的检测率为83%。这些发现首次描述了Odzala-Kokoua国家公园内或附近自由活动的大猩猩和黑猩猩粪便中的DNA病毒多样性，并为了解该地区大猩猩中传播的病毒类型奠定了基础。
Infectious diseases have caused die-offs in both free-ranging gorillas and chimpanzees. Understanding pathogen diversity and disease ecology is therefore critical for conserving these endangered animals. To determine viral diversity in free-ranging, non-habituated gorillas and chimpanzees in the Republic of Congo, genetic testing was performed on great-ape fecal samples collected near Odzala-Kokoua National Park. Samples were analyzed to determine ape species, identify individuals in the population, and to test for the presence of herpesviruses, adenoviruses, poxviruses, bocaviruses, flaviviruses, paramyxoviruses, coronaviruses, filoviruses, and simian immunodeficiency virus (SIV). We identified 19 DNA viruses representing two viral families, Herpesviridae and Adenoviridae, of which three herpesviruses had not been previously described. Co-detections of multiple herpesviruses and/or adenoviruses were present in both gorillas and chimpanzees. Cytomegalovirus (CMV) and lymphocryptovirus (LCV) were found primarily in the context of co-association with each other and adenoviruses. Using viral discovery curves for herpesviruses and adenoviruses, the total viral richness in the sample population of gorillas and chimpanzees was estimated to be a minimum of 23 viruses, corresponding to a detection rate of 83%. These findings represent the first description of DNA viral diversity in feces from free-ranging gorillas and chimpanzees in or near the Odzala-Kokoua National Park and form a basis for understanding the types of viruses circulating among great apes in this region.
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影响因子：
2.4
作者：
Devos, Celine;Sanz, Crickette;Huynen, Marie-Claude
通讯作者：
Huynen, Marie-Claude
影响因子：
3.3
作者：
Davison, AJ
通讯作者：
Davison, AJ
影响因子：
64.8
作者：
Jones KE;Patel NG;Levy MA;Storeygard A;Balk D;Gittleman JL;Daszak P
通讯作者：
Daszak P
影响因子：
56.9
作者：
Bermejo, Magdalena;Rodriguez-Teijeiro, Jose Domingo;Walsh, Peter D.
通讯作者：
Walsh, Peter D.
影响因子：
5
作者：
Chmielewicz, B;Goltz, M;Ehlers, B
通讯作者：
Ehlers, B