Quantitative cerebral MR perfusion imaging: preliminary results in stroke.
Quantitative cerebral MR perfusion imaging: preliminary results in stroke.
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DOI：
10.1002/jmri.22302
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发表时间：
2010-10
影响因子：
4.4
通讯作者：
Carroll, Timothy J.
中科院分区：
文献类型：
--
作者：
Shah, Maulin K.;Shin, Wanyong;Parikh, Vishal S.;Ragin, Ann;Mouannes, Jessy;Bernstein, Richard A.;Walker, Matthew T.;Bhatt, Hem;Carroll, Timothy J.
采用传统的基于时间的脑灌注测量或指标：脑卒中患者的达峰时间（Tmax）和平均通过时间（MTT）来评估定量脑血流量（qCBF）。9例缺血性卒中患者（4例男性，5例女性，63±16岁）入选本研究，该研究符合HIPAA要求，并获得机构审查委员会批准。使用Bookend方法定量脑灌注。在感兴趣区域（ROI）测定qCBF、Tmax和MTT的平均值。在扩散加权图像上分别对扩散阳性的严重缺血区（CI）、紧邻严重缺血区的同侧正常区（PP）和对侧扩散阴性对照区（PN）的灰质和白色物质（GM和WM）绘制ROI。在GM和WM中，qCBF测量区分所研究的脑区域，在对应于可能的缺血性损伤程度的区域中具有最显著降低的值。在计划的比较中，CI和PP组织之间仅qCBF测量值存在显著差异。ROC分析支持qCBF用于区分缺血性损伤可能程度不同的脑区域的效用（CI和PN区域- qCBF：AUC=0.96，Tmax：AUC=0.96，MTT：AUC=0.72）。重要的是，qCBF提供了CI和PP区域的最佳区分（qCBF：AUC=0.82，Tmax：AUC=0.65，MTT：AUC=0.52）。初步评价表明，定量MRI灌注在缺血性卒中患者中是可行的。与基于时间的成像指标相比，使用该策略导出的qCBF提供了增强的CI和PP区分。这种方法值得在更大的临床研究中进行调查。
To evaluate quantitative cerebral blood flow (qCBF) with traditional time-based measurements or metrics of cerebral perfusion: time to peak (Tmax) and mean transit time (MTT) in stroke patients. Nine ischemic stroke patients (4 Male, 5 Female, 63±16 years old) were included in the study which was HIPAA compliant and institutional review board approved. Cerebral perfusion was quantified using the Bookend method. Mean values of qCBF, Tmax, and MTT were determined in regions of interest (ROIs). ROIs were drawn on diffusion weighted images in diffusion positive, critically ischemic (CI), in ipsilateral normal region immediately surrounding the critically ischemic region, the presumed penumbra (PP), and in contralateral diffusion negative control, presumed normal region (PN) of gray and white matter separately (GM and WM). In both GM and WM, qCBF measures distinguished the studied brain regions with the most markedly reduced values in regions corresponding to extent of likely ischemic injury. In planned comparisons, only qCBF measurements differed significantly between CI and PP tissues. ROC analysis supported the utility of qCBF for discriminating brain regions differing in the likely extent of ischemic injury (CI and PN regions – qCBF: AUC=0.96, Tmax: AUC=0.96, MTT: AUC=0.72). Importantly, qCBF afforded the best discrimination of CI and PP regions (qCBF: AUC=0.82, Tmax: AUC=0.65, MTT: AUC=0.52). This initial evaluation indicates that quantitative MRI perfusion is feasible in ischemic stroke patients. qCBF derived with this strategy provide enhanced discrimination of CI and PP compared to time-based imaging metrics. This approach merits investigation in larger clinical studies.
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影响因子：
14.5
作者：
LEENDERS, KL;PERANI, D;JONES, T
通讯作者：
JONES, T
影响因子：
4.4
作者：
Lin, W;Celik, A;Powers, WJ
通讯作者：
Powers, WJ
影响因子：
9.9
作者：
Hakim, AM
通讯作者：
Hakim, AM
影响因子：
5
作者：
Obuchowski, NA
通讯作者：
Obuchowski, NA
DOI：
10.1097/00004647-199809000-00002
发表时间：
1998-09-01
影响因子：
6.3
作者：
Ostergaard, L;Johannsen, P;Gyldensted, C
通讯作者：
Gyldensted, C