Doubly labelled water-calibrated energy intake associations with mortality risk among older adults.
Doubly labelled water-calibrated energy intake associations with mortality risk among older adults.
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DOI：
10.1002/jcsm.13122
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发表时间：
2023-03
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影响因子：
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体重指数（BMI）与死亡风险密切相关，能量摄入（EI）是维持体重控制能量平衡的必要条件。然而，自我报告的EI已被证明会导致系统性低估。使用双标记水（DLW）方法测量的总能量消耗被认为是EI的客观生物标志物，并且是在体重稳定的个体中估计EI的金标准。我们的目的是检查DLW校准的EI和BMI之间的关系对老年人的总体死亡风险。使用来自日本京都-龟冈研究的8051名（4267名女性和3784名男性）日本老年人的数据进行了一项前瞻性队列研究。使用食物频率问卷和基于DLW开发的方程，根据估计的EI计算校准EI。根据按性别分层的EI，将参与者按四分位数进行分类。使用自我报告的身高和体重计算BMI。在2011年7月30日至2016年11月30日期间收集死亡率数据。使用多变量调整的考克斯比例风险模型和限制性三次样条进行统计分析。8051名参与者的平均（标准差）年龄和BMI分别为73.5（6.1）岁和22.6（3.0）kg/m2。在有和没有校准的情况下，女性的平均（标准差）EI分别为1909（145）kcal/天和1569（358）kcal/天，男性分别为2383（160）kcal/天和1980（515）kcal/天。在中位4.75年的随访期间（36552人年），记录了661例死亡。在女性（风险比[HR]，0.63; 95%置信区间[CI] [0.41，0.98]）和男性（HR，0.62; 95% CI [0.44，0.87]）中，在调整混杂因素后，与底部校准EI四分位数相比，顶部四分位数与全因死亡风险呈负相关。女性全因死亡的最低HR为1900-2000 kcal/天，男性为2400-2600 kcal/天。然而，在调整BMI后，没有观察到校准的EI和死亡风险之间的显著关联。这些关联在未校准的EI中无法得到证实。在BMI为23 kg/m2时，男性和女性的死亡率HR最小，有或没有校正校正的EI。校正后的EI与死亡风险呈负相关，但未校正的EI与死亡风险无关。这可能是由体重随时间增加介导的。在解释EI和死亡风险之间的关联时，需要谨慎，而不调整自我报告的测量误差和结局。
The body mass index (BMI) is closely related to mortality risk, and energy intake (EI) is essential for maintaining energy balance in weight control. However, self‐reported EI has been shown to lead to a systematic underestimation. Total energy expenditure measured using the doubly labelled water (DLW) method is considered an objective biomarker of EI and the gold standard for its estimation in individuals with stable body weight. We aimed to examine the association between DLW‐calibrated EI and BMI on overall mortality risk in older adults. A prospective cohort study was performed using data of 8051 (4267 women and 3784 men) Japanese older adults from the Kyoto–Kameoka Study in Japan. Calibrated EI was calculated from the estimated EI using a food frequency questionnaire and equation developed based on DLW. Participants were classified by quartiles based on their EI stratified by sex. BMI was calculated using self‐reported height and body weight. Mortality data were collected between 30 July 2011 and 30 November 2016. Statistical analysis was performed using the multivariable‐adjusted Cox proportional hazard model with a restricted cubic spline. The 8051 participants' mean (standard deviation) age and BMI were 73.5 (6.1) years and 22.6 (3.0) kg/m2, respectively. The mean (standard deviation) EI with and without calibration was 1909 (145) kcal/day and 1569 (358) kcal/day in women and 2383 (160) kcal/day and 1980 (515) kcal/day in men, respectively. During the median 4.75 years of follow‐up (36 552 person‐years), 661 deaths were recorded. In both women (hazard ratio [HR], 0.63; 95% confidence interval [CI] [0.41, 0.98]) and men (HR, 0.62; 95% CI [0.44, 0.87]), after adjusting for confounders, the top quartile as compared with the bottom calibrated EI quartile showed a negative association with risk of all‐cause mortality. The lowest HR for all‐cause mortality was 1900–2000 kcal/day in women and 2400–2600 kcal/day in men. However, after adjusting for BMI, no significant association was observed between the calibrated EI and the risk of death. These associations could not be confirmed in the uncalibrated EI. The HR for mortality was minimal at a BMI of 23 kg/m2 in both men and women, with or without adjustment for the calibrated EI. Calibrated EI was negatively associated with mortality risk but not uncalibrated EI. This may be mediated by an increase in body weight over time. Caution is required when interpreting the association between EI and mortality risk without adjusting for self‐reported measurement errors and outcomes.
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影响因子：
7.1
作者：
MAYER, J;ROY, P;MITRA, KP
通讯作者：
MITRA, KP
影响因子：
4.1
作者：
Watanabe, Daiki;Yoshida, Tsukasa;Watanabe, Yuya;Yamada, Yosuke;Miyachi, Motohiko;Kimura, Misaka
通讯作者：
Kimura, Misaka
流行病学和临床研究中缺少数据的多重归因：潜力和陷阱。
DOI：
10.1136/bmj.b2393
发表时间：
2009-06-29
期刊：
BMJ (Clinical research ed.)
影响因子：
--
作者：
Sterne JA;White IR;Carlin JB;Spratt M;Royston P;Kenward MG;Wood AM;Carpenter JR
通讯作者：
Carpenter JR
影响因子：
5.9
作者：
Hatamoto, Yoichi;Takae, Rie;Tanaka, Hiroaki
通讯作者：
Tanaka, Hiroaki
通过人类生活课程的每日能量消耗。
DOI：
10.1126/science.abe5017
发表时间：
2021-08-13
期刊：
Science (New York, N.Y.)
影响因子：
--
作者：
Pontzer H;Yamada Y;Sagayama H;Ainslie PN;Andersen LF;Anderson LJ;Arab L;Baddou I;Bedu-Addo K;Blaak EE;Blanc S;Bonomi AG;Bouten CVC;Bovet P;Buchowski MS;Butte NF;Camps SG;Close GL;Cooper JA;Cooper R;Das SK;Dugas LR;Ekelund U;Entringer S;Forrester T;Fudge BW;Goris AH;Gurven M;Hambly C;El Hamdouchi A;Hoos MB;Hu S;Joonas N;Joosen AM;Katzmarzyk P;Kempen KP;Kimura M;Kraus WE;Kushner RF;Lambert EV;Leonard WR;Lessan N;Martin C;Medin AC;Meijer EP;Morehen JC;Morton JP;Neuhouser ML;Nicklas TA;Ojiambo RM;Pietiläinen KH;Pitsiladis YP;Plange-Rhule J;Plasqui G;Prentice RL;Rabinovich RA;Racette SB;Raichlen DA;Ravussin E;Reynolds RM;Roberts SB;Schuit AJ;Sjödin AM;Stice E;Urlacher SS;Valenti G;Van Etten LM;Van Mil EA;Wells JCK;Wilson G;Wood BM;Yanovski J;Yoshida T;Zhang X;Murphy-Alford AJ;Loechl C;Luke AH;Rood J;Schoeller DA;Westerterp KR;Wong WW;Speakman JR;IAEA DLW Database Consortium
通讯作者：
IAEA DLW Database Consortium