Oleyl alcohol inhibits intestinal long-chain fatty acid absorption in rats.
Oleyl alcohol inhibits intestinal long-chain fatty acid absorption in rats.
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油醇抑制大鼠肠道长链脂肪酸吸收。
DOI：
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发表时间：
2000
影响因子：
1.6
通讯作者：
T. Fushiki
中科院分区：
文献类型：
--
作者：
K. Murota;T. Kawada;N. Matsui;M. Sakakibara;N. Takahashi;T. Fushiki
长链脂肪酸是重要的营养素，但肥胖是人类最常见的营养失调症。在这项研究中，我们研究了油醇对大鼠肠道长链脂肪酸吸收的影响。我们将[14C]油酸和油醇以脂质乳剂形式给予未麻醉的淋巴插管大鼠十二指肠内，并测量油酸的淋巴输出。其次，我们通过胃管口服脂肪乳剂并测量管腔和粘膜油酸残留。此外，给大鼠喂食油醇作为饮食成分20天，并测量粪便脂质和脂肪组织的重量。在淋巴插管大鼠中，与不存在油醇的情况相比，存在油醇的情况下，淋巴中甘油三酯和[14C]油酸的输出量显着降低，且呈剂量依赖性。口服油醇的大鼠肠腔中残留的放射性比对照组的大鼠更强烈。饲喂添加油醇的饮食的大鼠的粪便中脂质含量显着升高，并且其脂肪组织的重量显着低于对照组。这些结果表明，油醇抑制大鼠胃肠道对体内长链脂肪酸的吸收。
Long-chain fatty acids are important nutrients, but obesity is the most common nutritional disorder in humans. In this study we investigated the effect of oleyl alcohol on the intestinal long-chain fatty acid absorption in rats. We administered [14C]oleic acid and oleyl alcohol as lipid emulsion intraduodenally in unanesthetized lymph-cannulated rats and measured the lymphatic output of oleic acid. Second, we orally administered lipid emulsion with a stomach tube and measured the luminal and mucosal oleic acid residues. Furthermore, rats were fed oleyl alcohol as a dietary component for 20 days, and fecal lipid and the weight of adipose tissues were measured. In lymph-cannulated rats, triglyceride and [14C]oleic acid output in the lymph were significantly lower in the presence of oleyl alcohol when compared with the absence of oleyl alcohol in a dose-dependent manner. The radioactivity remaining in the intestinal lumen was more strongly detected in rats that had been orally administered oleyl alcohol than in the controls. The feces of rats fed an oleyl-alcohol-added diet contained much higher amounts of lipids, and the weights of their adipose tissues were significantly lower than in the control group. These results suggest that oleyl alcohol inhibits the rat gastrointestinal absorption of long-chain fatty acids in vivo.
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影响因子：
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作者：
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DOI：
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发表时间：
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期刊：
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影响因子：
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作者：
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