Nutritional correlates and dynamics of diabetes in the Nile rat (Arvicanthis niloticus): a novel model for diet-induced type 2 diabetes and the metabolic syndrome.
Nutritional correlates and dynamics of diabetes in the Nile rat (Arvicanthis niloticus): a novel model for diet-induced type 2 diabetes and the metabolic syndrome.
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DOI：
10.1186/1743-7075-7-29
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发表时间：
2010-04-15
影响因子：
4.5
通讯作者：
Hayes K
中科院分区：
文献类型：
--
作者：
Chaabo F;Pronczuk A;Maslova E;Hayes K
在美国和全世界，代谢综合征和相关慢性疾病（其中包括非胰岛素依赖型（2型）糖尿病）的患病率正在上升。对环境应激源（如饮食）作出反应的动物模型可用于研究这些相关疾病的结果和发展。在这种情况下，生长和能量的关系，其特征在于在尼罗河大鼠，一种外来的非洲啮齿动物，作为一个潜在的动物模型饮食诱导的2型糖尿病和代谢综合征。几项研究的汇编数据确定了年龄、体重增加（包括腹部肥胖）、食物和水消耗量以及血糖水平之间的关系，作为雄性和雌性尼罗大鼠糖尿病的决定因素。葡萄糖耐量试验、胰岛素、HbA 1c、血压测量和血浆脂质进一步表征了与代谢综合征标准相关的糖尿病，而高脂肪、低纤维或食物限制的饮食改变试图调节疾病。喂食实验室食物的Nile大鼠表现出代谢综合征的体征，其演变为饮食诱导的非胰岛素依赖性（2型）糖尿病，其特征为高胰岛素血症伴血糖升高（胰岛素抵抗）、腹部肥胖和葡萄糖清除受损（在食物和水摄入增加之前）以及HbA 1c升高、血浆甘油三酯和胆固醇显著升高、微量白蛋白尿和高血压。男性比女性更容易迅速进展为糖尿病，这取决于挑战饮食。在男性糖尿病分为早发性和晚发性组，前者与更快的增长和更大的增长效率的热量消耗。有趣的是，在长期研究中，老年雄性尼罗大鼠的血糖和体重指数（总体肥胖）之间没有相关性，而血糖和肾周脂肪垫以及肝脏和肾脏重量与早发性糖尿病呈正相关。早期断奶（4-5周）并用高脂肪西式饮食激发的大鼠更快地患上糖尿病，并且体内脂肪积累更明显，而食物限制则减少了它。喂食典型啮齿动物饮食的尼罗大鼠在高血糖症（胰岛素抵抗）之前发展高胰岛素血症，导致与高血糖症、高胆固醇血症和高血压相关的饮食诱导的2型糖尿病。饮食调节影响生长速率（体重增加和中心性肥胖），从而影响疾病进展。这种啮齿动物模型代表了影响能量利用的基因-饮食相互作用的新系统，可以为2型糖尿病和代谢综合征的预防和治疗提供见解。
The prevalence of Metabolic Syndrome and related chronic diseases, among them non-insulin-dependent (type 2) diabetes mellitus, are on the rise in the United States and throughout the world. Animal models that respond to environmental stressors, such as diet, are useful for investigating the outcome and development of these related diseases. Within this context, growth and energy relationships were characterized in the Nile rat, an exotic African rodent, as a potential animal model for diet-induced type 2 diabetes mellitus and Metabolic Syndrome. Compiled data from several studies established the relationship between age, body weight gain (including abdominal adiposity), food and water consumption, and blood glucose levels as determinants of diabetes in male and female Nile rats. Glucose Tolerance Testing, insulin, HbA1c, blood pressure measurements and plasma lipids further characterized the diabetes in relation to criteria of the Metabolic Syndrome, while diet modification with high-fat, low-fiber or food restriction attempted to modulate the disease. The Nile rat fed lab chow demonstrates signs of the Metabolic Syndrome that evolve into diet-induced non-insulin-dependent (type 2) diabetes mellitus characterized by hyperinsulinemia with rising blood glucose (insulin resistance), abdominal adiposity, and impaired glucose clearance that precedes increased food and water intake, as well as elevated HbA1c, marked elevation in plasma triglycerides and cholesterol, microalbuminuria, and hypertension. Males are more prone than females with rapid progression to diabetes depending on the challenge diet. In males diabetes segregated into early-onset and late-onset groups, the former related to more rapid growth and greater growth efficiency for the calories consumed. Interestingly, no correlation was found between blood glucose and body mass index (overall adiposity) in older male Nile rats in long term studies, whereas blood glucose and the perirenal fat pad, as well as liver and kidney weight, were positively related to early-onset diabetes. Rats weaned early (4-5 wks) and challenged with a high-fat Western-type diet developed diabetes faster, and body fat accumulation was more apparent, whereas food restriction curtailed it. The Nile rat fed typical rodent diets develops hyperinsulinemia that precedes hyperglycemia (insulin resistance) leading to diet-induced type 2 diabetes associated with hypertriglyceridemia, hypercholesterolemia, and hypertension. Dietary modulation affected growth rate (weight gain and central adiposity) to impact disease progression. This rodent model represents a novel system of gene-diet interactions affecting energy utilization that can provide insight into the prevention and treatment of the type 2 diabetes and Metabolic Syndrome.
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影响因子：
1
作者：
DELANY, MJ;MONRO, RH
通讯作者：
MONRO, RH
影响因子：
1.6
作者：
El Aoufi, S.;Gendre, P.;Griene, L.
通讯作者：
Griene, L.
影响因子：
--
作者：
HAINES, H;HACKEL, DB;SCHMIDTN.K
通讯作者：
SCHMIDTN.K
糖尿病的医疗标准 - 2009年。
影响因子：
16.2
作者：
American Diabetes Association
通讯作者：
American Diabetes Association
影响因子：
8.3
作者：
Brands, MW;Hopkins, TE
通讯作者：
Hopkins, TE