The landscape of miRNA editing in animals and its impact on miRNA biogenesis and targeting.
The landscape of miRNA editing in animals and its impact on miRNA biogenesis and targeting.
复制标题
动物中 miRNA 编辑的概况及其对 miRNA 生物发生和靶向的影响。
DOI：
10.1101/gr.224386.117
复制
发表时间：
2018-01
期刊：
影响因子：
7
通讯作者：
Zhang R
中科院分区：
文献类型：
--
作者：
Li L;Song Y;Shi X;Liu J;Xiong S;Chen W;Fu Q;Huang Z;Gu N;Zhang R
腺苷到肌苷（A-to-I）RNA编辑调节miRNA生物发生和功能。到目前为止，已经确定了不到160个miRNA编辑位点。在这里，我们通过分析人类、小鼠和果蝇中的201个pri-miRNA样本和4694个成熟miRNA样本，提出了一个miRNA A-to-I编辑的定量图谱。我们鉴定了4162个位点存在于约80%的pri-miRNAs中，574个位点存在于成熟miRNAs中。miRNA编辑在人类的许多组织类型中普遍存在。然而，高水平编辑主要存在于小鼠和果蝇的神经元组织中。有趣的是，人类神经元和非神经元组织中编辑的miRNA获得了两组不同的新靶标，它们分别与认知和器官发育功能显著相关。此外，我们揭示了miRNA编辑深刻地影响不对称链选择。总之，这些数据提供了深入了解RNA编辑对miRNA生物学的影响，并表明miRNA编辑最近在人类中获得了非神经元功能。
Adenosine-to-inosine (A-to-I) RNA editing regulates miRNA biogenesis and function. To date, fewer than 160 miRNA editing sites have been identified. Here, we present a quantitative atlas of miRNA A-to-I editing through the profiling of 201 pri-miRNA samples and 4694 mature miRNA samples in human, mouse, and Drosophila. We identified 4162 sites present in ∼80% of the pri-miRNAs and 574 sites in mature miRNAs. miRNA editing is prevalent in many tissue types in human. However, high-level editing is mostly found in neuronal tissues in mouse and Drosophila. Interestingly, the edited miRNAs in neuronal and non-neuronal tissues in human gain two distinct sets of new targets, which are significantly associated with cognitive and organ developmental functions, respectively. Furthermore, we reveal that miRNA editing profoundly affects asymmetric strand selection. Altogether, these data provide insight into the impact of RNA editing on miRNA biology and suggest that miRNA editing has recently gained non-neuronal functions in human.
登录
查看更多内容
影响因子：
14.9
作者：
Kume H;Hino K;Galipon J;Ui-Tei K
通讯作者：
Ui-Tei K
影响因子：
12.3
作者：
Blow MJ;Grocock RJ;van Dongen S;Enright AJ;Dicks E;Futreal PA;Wooster R;Stratton MR
通讯作者：
Stratton MR
影响因子：
14.9
作者：
Kawahara, Yukio;Megraw, Molly;Kreider, Edward;Iizasa, Hisashi;Valente, Louis;Hatzigeorgiou, Artemis G.;Nishikura, Kazuko
通讯作者：
Nishikura, Kazuko
影响因子：
64.8
作者：
Graveley BR;Brooks AN;Carlson JW;Duff MO;Landolin JM;Yang L;Artieri CG;van Baren MJ;Boley N;Booth BW;Brown JB;Cherbas L;Davis CA;Dobin A;Li R;Lin W;Malone JH;Mattiuzzo NR;Miller D;Sturgill D;Tuch BB;Zaleski C;Zhang D;Blanchette M;Dudoit S;Eads B;Green RE;Hammonds A;Jiang L;Kapranov P;Langton L;Perrimon N;Sandler JE;Wan KH;Willingham A;Zhang Y;Zou Y;Andrews J;Bickel PJ;Brenner SE;Brent MR;Cherbas P;Gingeras TR;Hoskins RA;Kaufman TC;Oliver B;Celniker SE
通讯作者：
Celniker SE
DOI：
10.1111/j.2517-6161.1995.tb02031.x
发表时间：
1995-01-01
影响因子：
5.8
作者：
BENJAMINI, Y;HOCHBERG, Y
通讯作者：
HOCHBERG, Y