Periventricular and deep abnormal white matter differ in associations with cognitive performance at midlife.
Periventricular and deep abnormal white matter differ in associations with cognitive performance at midlife.
复制标题
脑室周围和深部异常白色物质与中年认知能力的相关性不同。
DOI：
10.1037/neu0000718
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发表时间：
2021-03
期刊：
影响因子：
2.4
通讯作者：
Kremen WS
中科院分区：
文献类型：
--
作者：
Sanderson-Cimino M;Panizzon MS;Elman JA;Tu X;Gustavson DE;Puckett O;Cross K;Notestine R;Hatton SN;Eyler LT;McEvoy LK;Hagler DJ;Neale MC;Gillespie NA;Lyons MJ;Franz CE;Fennema-Notestine C;Kremen WS
磁共振成像中异常白色物质（AWM）与老年人的认知能力有关。我们探索了中年晚期与AWM的认知联系。参与者为社区居民男性（n = 242; M = 61.90岁;范围= 56-66）。线性混合效应回归模型检查了总AWM、室周AWM和深部AWM与认知能力的相关性，并控制了多重比较。模型考虑特定的认知领域控制当前的一般认知能力（GCA）。我们假设，总AWM将与更差的处理速度，执行功能和当前GCA相关;深层AWM将与GCA相关，脑室周围AWM将与特定的认知能力相关。我们还通过研究早期生活（平均年龄20岁）认知的调节效应来评估认知储备的潜在影响。较大的总AWM和深部AWM与较差的当前GCA相关。脑室周围AWM与较差的执行功能、工作记忆和情景记忆相关。当脑室周围和深部AWM同时建模时，两者都保留了各自与认知表现的显著相关性。认知储备并没有缓和关联。我们的研究结果表明，AWM有助于在中年后期认知功能较差。仅审查总体AWM可能会掩盖区域AWM的潜在差异影响。将总AWM分为亚型，同时控制当前的GCA，揭示了与认知性能的关系分离;深部AWM与非特异性认知能力相关，而脑室周围AWM与特定的额叶相关能力和记忆相关。可能增加AWM风险的血管或其他风险因素的管理应在中年早期或之前开始。
Abnormal white matter (AWM) on magnetic resonance imaging is associated with cognitive performance in older adults. We explored cognitive associations with AWM during late-midlife. Participants were community-dwelling men (n = 242; M = 61.90 years; range = 56–66). Linear-mixed effects regression models examined associations of total, periventricular, and deep AWM with cognitive performance, controlling for multiple comparisons. Models considering specific cognitive domains controlled for current general cognitive ability (GCA). We hypothesized that total AWM would be associated with worse processing speed, executive function, and current GCA; deep AWM would correlate with GCA and periventricular AWM would relate to specific cognitive abilities. We also assessed the potential influence of cognitive reserve by examining a moderation effect of early life (mean age of 20) cognition. Greater total and deep AWM were associated with poorer current GCA. Periventricular AWM was associated with worse executive function, working memory, and episodic memory. When periventricular and deep AWM were modeled simultaneously, both retained their respective significant associations with cognitive performance. Cognitive reserve did not moderate associations. Our findings suggest that AWM contributes to poorer cognitive function in late-midlife. Examining only total AWM may obscure the potential differential impact of regional AWM. Separating total AWM into subtypes while controlling for current GCA revealed a dissociation in relationships with cognitive performance; deep AWM was associated with nonspecific cognitive ability whereas periventricular AWM was associated with specific frontal-related abilities and memory. Management of vascular or other risk factors that may increase the risk of AWM should begin during or before early late-midlife.
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影响因子：
2.6
作者：
Bolandzadeh N;Davis JC;Tam R;Handy TC;Liu-Ambrose T
通讯作者：
Liu-Ambrose T
DOI：
10.1136/bmj.c3666
发表时间：
2010-07-26
期刊：
BMJ (Clinical research ed.)
影响因子：
--
作者：
Debette S;Markus HS
通讯作者：
Markus HS
影响因子：
3.5
作者：
Christensen, Helen;Anstey, Kaarin J.;Sachdev, Perminder
通讯作者：
Sachdev, Perminder
影响因子：
8.3
作者：
DeCarli, C;Fletcher, E;Jagust, WJ
通讯作者：
Jagust, WJ
影响因子：
8.3
作者：
Doubal, Fergus N.;MacLullich, Alasdair M. J.;Wardlaw, Joanna M.
通讯作者：
Wardlaw, Joanna M.