Diet, body size and menarche in a multiethnic cohort.

Diet, body size and menarche in a multiethnic cohort.
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DOI:
10.1038/sj.bjc.6690303
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发表时间:
1999-04
影响因子:
8.8
通讯作者:
Bernstein, L
Bernstein, L
中科院分区:
医学1区
文献类型:
--
作者:
Koprowski, C;Ross, RK;Mack, WJ;Henderson, BE;Bernstein, L

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对1378名8-13岁的南加州女学生的多种族队列进行了4年的随访,以评估预测初潮年龄的因素,初潮年龄是乳腺癌的危险因素。测量身高和体重,并使用半定量食物频率问卷评估饮食摄入量。在939名提供月经初潮状况数据的女孩中,767名在研究开始时处于月经初潮期; 679名女孩提供了可接受的饮食数据,并被纳入分析。考克斯比例风险模型被用来评估饮食,体型,种族和初潮年龄之间的关系。西班牙裔、亚洲/太平洋岛屿和非洲裔美国女孩比非西班牙裔白色女孩更容易经历初潮。高个子(> 148.6 cm)女孩比矮个子(< 135.9 cm)女孩的初潮更早(相对危险度(RH)= 2.9,95%置信区间(CI)2.1-4.1),高克托莱指数(QI,kg m−2)(> 20.7)女孩比低克托莱指数(< 16.1)女孩的初潮更早(RH = 2.2,95% CI 1.7-2.9)。所有的饮食变量分析,只有能量摄入量与初潮年龄。高与低能量摄入(> 12013 kJ vs < 7004 kJ)与月经初潮延迟相关(RH = 0.7,95% CI 0.5-0.9);这一发现仅限于一部分体重较重的西班牙裔女孩,她们似乎低估了自己的饮食摄入量。© 1999癌症研究运动
A multiethnic cohort of 1378 Southern California school girls aged 8–13 years was followed for 4 years to evaluate factors predicting age at menarche, a risk factor for breast cancer. Height and weight were measured and dietary intake was assessed using a semi-quantitative food frequency questionnaire. Of 939 girls providing data on menarcheal status, 767 were premenarcheal at the start of the study; 679 girls provided acceptable dietary data and were included in the analyses. Cox proportional hazards models were used to assess the relationship between diet, body size, ethnicity and age at menarche. Hispanic, Asian/Pacific Island and African-American girls were more likely to experience early menarche than non-Hispanic white girls. Tall (> 148.6 cm) versus short (< 135.9 cm) girls experienced earlier menarche (relative hazard (RH) = 2.9, 95% confidence interval (CI) 2.1–4.1) as did those with high Quetelet's index (QI, kg m−2) (> 20.7) versus low QI (< 16.1) (RH = 2.2, 95% CI 1.7–2.9). Of all the dietary variables analysed, only energy intake was related to age at menarche. High versus low energy intake (> 12013 kJ vs < 7004 kJ) was associated with a delay in menarche (RH = 0.7, 95% CI 0.5–0.9); this finding was limited to a subset of heavy Hispanic girls who appeared to underreport their dietary intake. © 1999 Cancer Research Campaign
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