Effects of carotenoid-rich food extracts on the development of preneoplastic lesions in rat liver and on in vivo and in vitro antioxidant status.
Effects of carotenoid-rich food extracts on the development of preneoplastic lesions in rat liver and on in vivo and in vitro antioxidant status.
复制标题
富含类胡萝卜素的食物提取物对大鼠肝脏癌前病变的发展以及体内和体外抗氧化状态的影响。
DOI：
10.1080/01635589709514532
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发表时间：
1997
期刊：
影响因子：
--
通讯作者：
T. Campbell
中科院分区：
文献类型：
--
作者：
Youping He;M. Root;R. Parker;T. Campbell
研究了富含类胡萝卜素的胡萝卜、西红柿和橙汁膳食提取物对黄曲霉毒素 B1 诱导的大鼠肝脏 γ-谷氨酰转肽酶阳性癌前病灶的影响。从食物中制备有机提取物，将其溶解在三辛精油中，使其与主要食物特异性类胡萝卜素的浓度相当，并通过插管喂养 Fischer 344 只雄性大鼠。在研究的 2 周黄曲霉毒素给药（起始）期间或随后的 12 周给药后（促进）期间施用提取物。测量血液和肝脏中的维生素状态和抗氧化活性。提取物喂养导致类胡萝卜素在肝脏中积聚，自发性红细胞溶血大幅减少，并降低血浆谷胱甘肽、血液超氧化物歧化酶和血液过氧化氢酶。三种提取物之间病灶发育的差异并不像起始剂量和促进剂量之间的差异那么一致或深刻。起始期提取物喂养减少了γ-谷氨酰转肽酶阳性病灶的数量，而促进期提取物喂养导致病灶平均直径减小。在任一时期，通过提取物喂养，病灶的总体积显着减少。将提取物与纯化的类胡萝卜素和α-生育酚影响体外抗氧化活性的能力进行比较，并且几乎与纯化合物一样有效。总之，这三种食物中富含类胡萝卜素的提取物显着抑制了被认为在肝癌早期阶段发挥作用的生化和细胞事件。
The effect of dietary carotenoid-rich extracts of carrots, tomatoes, and orange juice on rat liver gamma-glutamyl transpeptidase-positive preneoplastic foci induced by aflatoxin B1 was investigated. Organic extracts were prepared from the foods, dissolved in tricaprylin oil to equivalent concentrations of the major food-specific carotenoids, and fed by intubation to Fischer 344 male rats. The extracts were administered during the 2-week aflatoxin-dosing (initiation) period of the study or during the subsequent 12-week post-dosing (promotion) period. Vitamin status and antioxidant activities were measured in blood and liver. Extract feeding caused an accumulation of carotenoids in the liver, a substantial decrease in spontaneous erythrocyte hemolysis, and lowered plasma glutathione, blood superoxide dismutase, and blood catalase. Differences in foci development among the three extracts were not as consistent or profound as differences between initiation and promotion dosing. The number of gamma-glutamyl transpeptidase-positive foci was decreased by extract feeding during the initiation period, whereas extract feeding during the promotion period caused a decrease in the average diameter of the foci. The total volume of foci was markedly reduced by extract feeding during either period. Extracts were compared with purified carotenoids and alpha-tocopherol in their ability to affect in vitro antioxidation activity and were nearly as effective as the pure compounds. In summary, carotenoid-rich extracts of these three foods substantially inhibited biochemical and cellular events thought to play a role in the early stages of hepatocarcinogenesis.
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影响因子：
56.9
作者：
AMES, BN
通讯作者：
AMES, BN
缺乏蛋白质的猪在受到炎症应激时无法维持还原型谷胱甘肽的稳态。
DOI：
10.1093/jn/125.6.1462
发表时间：
1995
期刊：
The Journal of nutrition
影响因子：
--
作者：
Jahoor,F;Wykes,LJ;Reeds,PJ;Henry,JF;delRosario,MP;Frazer,ME
通讯作者：
Frazer,ME
低蛋白饮食对黄曲霉毒素 B1 诱导的 γ-谷氨酰转肽酶阳性 (GGT) 肝肿瘤前病灶和肿瘤的抑制：GGT 病灶改变表明肿瘤潜力的证据。
影响因子：
4.7
作者：
Youngman,LD;Campbell,TC
通讯作者：
Campbell,TC
影响因子：
158.5
作者：
Omenn, GS;Goodman, GE;Hammar, S
通讯作者：
Hammar, S
影响因子：
158.5
作者：
Hennekens, CH;Buring, JE;Peto, R
通讯作者：
Peto, R