ABCDs of the Relative Contributions of Pseudomonas aeruginosa Quorum Sensing Systems to Virulence in Diverse Nonvertebrate Hosts.
ABCDs of the Relative Contributions of Pseudomonas aeruginosa Quorum Sensing Systems to Virulence in Diverse Nonvertebrate Hosts.
复制标题
作者：
铜绿假单胞菌是一种机会致病菌，在非常广泛的植物和动物中表现出致病性，并且研究不同宿主中特定毒力相关因子的作用是令人感兴趣的。许多铜绿假单胞菌毒力因子的产生是在群体感应（QS）信号传导网络的控制下，该网络具有参与复杂串扰的三个相互连接的分支：Las、Rhl和MvfR。由于还没有系统地比较三种QS系统在介导铜绿假单胞菌在各种宿主中的毒力中的作用，我们比较了野生型（WT）铜绿假单胞菌PA 14和一组同基因PA 14 QS框内缺失突变体在四种选定宿主（参考植物拟南芥）中的毒力（拟南芥属）、作物植物欧洲油菜（油菜）、线虫秀丽隐杆线虫（Caillumhabditis elegans）和果蝇（Drosophila melanogaster）。所选宿主属的首字母A、B、C和D启发了本文的标题，并表明这项工作为今后阐明每个QS分支在不同宿主中介导毒力的具体作用奠定了基础。
Pseudomonas aeruginosa is an opportunistic bacterial pathogen that exhibits pathogenicity in an unusually broad range of plants and animals, and it is of interest to study the roles of particular virulence-related factors in diverse hosts. The production of many P. aeruginosa virulence factors is under the control of a quorum sensing (QS) signaling network, which has three interconnected branches that engage in intricate cross talk: Las, Rhl, and MvfR. Because there has been no systematic comparison of the roles of the three QS systems in mediating P. aeruginosa virulence in various hosts, we compared the virulence of wild-type (WT) P. aeruginosa PA14 and a set of isogenic PA14 QS in-frame deletion mutants in four selected hosts, the reference plant Arabidopsis thaliana (Arabidopsis), the crop plant Brassica napus (canola), the nematode Caenorhabditis elegans, and the fruit fly Drosophila melanogaster. The first letters of the selected host genera, A, B, C, and D, inspired the title of this article and indicate that this work lays the groundwork for future elucidation of the specific roles of each QS branch in mediating virulence in diverse hosts.
登录
查看更多内容
DOI：
10.1073/pnas.1814023115
发表时间：
2018-10-02
影响因子：
11.1
作者：
Mukherjee S;Moustafa DA;Stergioula V;Smith CD;Goldberg JB;Bassler BL
通讯作者：
Bassler BL
影响因子：
48
作者：
Stroustrup, Nicholas;Ulmschneider, Bryne E.;Nash, Zachary M.;Lopez-Moyado, Isaac F.;Apfeld, Javier;Fontana, Walter
通讯作者：
Fontana, Walter
影响因子：
7.7
作者：
Haller, Samantha;Franchet, Adrien;Ferrandon, Dominique
通讯作者：
Ferrandon, Dominique
影响因子：
56.9
作者：
PASSADOR, L;COOK, JM;IGLEWSKI, BH
通讯作者：
IGLEWSKI, BH
影响因子：
2.8
作者：
Diggle, Stephen P.;Whiteley, Marvin
通讯作者：
Whiteley, Marvin