Genetic influences on hub connectivity of the human connectome.
Genetic influences on hub connectivity of the human connectome.
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DOI：
10.1038/s41467-021-24306-2
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发表时间：
2021-07-09
影响因子：
16.6
通讯作者：
Fornito A
中科院分区：
文献类型：
--
作者：
Arnatkeviciute A;Fulcher BD;Oldham S;Tiego J;Paquola C;Gerring Z;Aquino K;Hawi Z;Johnson B;Ball G;Klein M;Deco G;Franke B;Bellgrove MA;Fornito A
脑网络枢纽是高度连接和高度互联的，是连贯神经动力学的关键通信骨干。人们对驱动这种组织的机制知之甚少。利用双胞胎的扩散加权磁共振成像，我们确定了基因的主要作用，表明它们优先影响人类连接组网络枢纽之间的连接强度。利用转录组图谱数据，我们发现连接的枢纽显示出与代谢和细胞结构相似性相关的转录活性的紧密耦合。最后，通过比较13种以上的网络增长生成模型，我们发现纯粹的随机过程不能解释枢纽的精确布线模式，并且可以通过纳入遗传约束来提高模型的性能。我们的研究结果表明，基因在形成连接组枢纽之间具有功能价值、代谢成本高的连接方面发挥着强大而优先的作用。基因如何塑造人类连接体的复杂结构仍不清楚。在这里，作者表明，基因优先影响功能上有价值的连接强度，大脑网络枢纽之间代谢昂贵的连接。
Brain network hubs are both highly connected and highly inter-connected, forming a critical communication backbone for coherent neural dynamics. The mechanisms driving this organization are poorly understood. Using diffusion-weighted magnetic resonance imaging in twins, we identify a major role for genes, showing that they preferentially influence connectivity strength between network hubs of the human connectome. Using transcriptomic atlas data, we show that connected hubs demonstrate tight coupling of transcriptional activity related to metabolic and cytoarchitectonic similarity. Finally, comparing over thirteen generative models of network growth, we show that purely stochastic processes cannot explain the precise wiring patterns of hubs, and that model performance can be improved by incorporating genetic constraints. Our findings indicate that genes play a strong and preferential role in shaping the functionally valuable, metabolically costly connections between connectome hubs. How genes sculpt the complex architecture of the human connectome remains unclear. Here, the authors show that genes preferentially influence the strength of connectivity between functionally valuable, metabolically costly connections between brain network hubs.
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影响因子：
4.6
作者：
Beul SF;Barbas H;Hilgetag CC
通讯作者：
Hilgetag CC
影响因子：
5.3
作者：
Baker, Simon T. E.;Lubman, Dan I.;Fornito, Alex
通讯作者：
Fornito, Alex
影响因子：
3
作者：
Boker S;Neale M;Maes H;Wilde M;Spiegel M;Brick T;Spies J;Estabrook R;Kenny S;Bates T;Mehta P;Fox J
通讯作者：
Fox J
影响因子：
4.7
作者：
Betzel, Richard F.;Griffa, Alessandra;Misic, Bratislav
通讯作者：
Misic, Bratislav
DOI：
10.1111/j.2517-6161.1995.tb02031.x
发表时间：
1995-01-01
影响因子：
5.8
作者：
BENJAMINI, Y;HOCHBERG, Y
通讯作者：
HOCHBERG, Y