Association between a variant in microRNA-646 and the susceptibility to hepatocellular carcinoma in a large-scale population.
Association between a variant in microRNA-646 and the susceptibility to hepatocellular carcinoma in a large-scale population.
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MicroRNA-646 变异与大规模人群肝细胞癌易感性之间的关联
DOI：
10.1155/2014/312704
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发表时间：
2014
影响因子：
--
通讯作者：
Liu J
中科院分区：
文献类型：
--
作者：
Wang R;Zhang J;Jiang W;Ma Y;Li W;Jin B;Hu H;Wang J;Liu Y;Liu J
背景。microRNAs的单核苷酸多态性在肿瘤发生和癌症发展中起着重要作用。目标。我们的目的是探讨miR-646 rs6513497是否与肝细胞癌的风险相关。方法。本研究共纳入997例HCC患者和993例无癌对照。采用MassARRAY方法进行基因分型。结果。与rs6513497的T等位基因相比，G等位基因与HCC发生风险显著降低相关（OR = 0.788, 95% CI = 0.631-0.985, P = 0.037）；此外，G等位基因在男性中表现出更强的保护作用（HCC OR = 0.695, 95% CI = 0.539-0.897, P = 0.005； hbv相关HCC OR = 0.739, 95% CI = 0.562-0.972, P = 0.030），且基本呈显性（HCC OR = 0.681, 95% CI = 0.162-0.896, P = 0.006； hbv相关HCC OR = 0.715, 95% CI = 0.532-0.962, P = 0.027）。结论。我们的研究结果支持miR-646 SNP rs6513497可能与HCC易感性有关的观点。
Background. Single-nucleotide polymorphisms in microRNAs play important roles in oncogenesis and cancer development. Objective. We aim to explore whether miR-646 rs6513497 is associated with the risk of hepatocellular carcinoma. Methods. Total 997 HCC patients and 993 cancer-free controls were enrolled in this study. Genotyping was performed using MassARRAY method. Results. Compared with the T allele of rs6513497, the G allele was associated with a significantly decreased risk of HCC (OR = 0.788, 95% CI = 0.631–0.985, P = 0.037); moreover, a more protective effect of the G allele was shown in males (OR = 0.695, 95% CI = 0.539–0.897, P = 0.005 in HCC and OR = 0.739, 95% CI = 0.562–0.972, P = 0.030 in HBV-related HCC), basically in a dominant manner (HCC: OR = 0.681, 95% CI = 0.162–0.896, P = 0.006; HBV-related HCC: OR = 0.715, 95% CI = 0.532–0.962, P = 0.027). Conclusions. Our findings support the view that the miR-646 SNP rs6513497 may contribute to the susceptibility of HCC.
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DOI：
10.1007/s00432-013-1456-7
发表时间：
2013-08-01
影响因子：
3.6
作者：
Lv, Meili;Dong, Wei;Zhang, Lin
通讯作者：
Zhang, Lin
影响因子：
5.6
作者：
Finnerty JR;Wang WX;Hébert SS;Wilfred BR;Mao G;Nelson PT
通讯作者：
Nelson PT
影响因子：
3.5
作者：
Duan, Ranhui;Pak, ChangHui;Jin, Peng
通讯作者：
Jin, Peng
影响因子：
--
作者：
Zhang, Jun;Wang, Rui;Liu, Jie
通讯作者：
Liu, Jie
影响因子：
5.3
作者：
Slaby O;Bienertova-Vasku J;Svoboda M;Vyzula R
通讯作者：
Vyzula R